短期胰岛素泵治疗对初诊2型糖尿病患者胰岛β细胞功能的影响(1)
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[摘要] 目的 观察短期应用胰岛素泵治疗对初诊2型糖尿病患者血糖、胰岛β细胞功能和胰岛素敏感性的影响。方法 用胰岛素泵对72例初诊2型糖尿病患者进行2周的持续皮下胰岛素输注(CSII)，观察并记录治疗前后空腹血糖(FPG)及餐后2h血糖(2hPG)、糖化血红蛋白A1c(HbA1c)、空腹胰岛素(FINS)、餐后2h胰岛素(2hINS)、胰岛素分泌指数(HOMA-β)、早期胰岛素分泌指数胰岛素抵抗指数(HOMA-IR)。计算胰岛素及葡萄糖曲线下面积(AUCI，AUCG)。结果 CSII治疗能快速稳定控制血糖，治疗2周后 FINS及HOMA-β明显上升，HOMA-IR明显下降(P<0.01)。结论 短期CSII治疗对2型糖尿病有快速稳定血糖、改善胰岛β细胞功能和降低胰岛素抵抗的作用。
[关键词] 2型糖尿病；持续皮下胰岛素输注；胰岛β细胞功能；胰岛素抵抗
[中图分类号] R587.1[文献标识码] B[文章编号] 1673-9701(2011)20-50-02
Effect of Short-term Continuous Subcutaneous Insulin Infusion Treatment on Beta-cell Function and Insulin Resistance in Type 2 Diabetic Patient
LI Hao1LIANG Yudong2
1.Department of Laboratory of Runan County People’s Hospital，Runan 463300，China；2. Department of Digests of Runan County People’s Hospital，Runan 463300，China
[Abstract] ObjectiveTo observe the effect of short-term continuous subcutaneous insulin infusion(CSII) on blood glucose，beta-cell function and insulin resistance in patients with newly-diagnosed type 2 diabetes mellitus. MethodsSeventy-two patients with newly-diagnosed type 2 diabetes mellitus receiving two weeks of CSII therapy were analyzed . The levels of the fasting plasma glucose (FPG)，2 hours postpradial glucose(2hPG)，and glycosylated hemoglobin A1c(HbA1c)，fast insulin (FINS)，2 hours postpradial insulin and insulin secretion indexes(HOMA-β) and insulin resistance index(HOMA-IR) were determined and compared before and after CSII. ResultsThe level of blood glucose was well stably controlled by CSII. The levels of FINS，HOMA-B were increased significantly two weeks after intensive treatment with CSII. The HOMA-IR were decreased significantly.Conclusion Short-term CSII intensive treatment can stably control the level of blood sugar，improve the function of beta-cell and reduce the resistance to insulin in type 2 diabetic patients.
[Key words ] Type 2 Diabetes；Continuous subcutaneous insulin infusion； Islet β cell function；Insulin resistance
2型糖尿病是一种缓慢进展性疾病，β细胞功能进行性下降是其发病和病情进展的基础。糖尿病患者血糖水平与发生并发症的风险性成正比，引起的各种急、慢性并发症威胁着人们的健康 ......
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