癌胚抗原和CA19-9联合检测对Ⅳ期胃癌腹膜转移的诊断价值(1)
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[摘要] 目的 探讨癌胚抗原和CA19-9联合检测对Ⅳ期胃癌腹膜转移的诊断价值，方法 分别测定2008年1月～2010年1月我院收治的119例Ⅳ期胃癌腹膜转移患者和151例同期Ⅳ期胃癌无腹膜转移患者的癌胚抗原和CA19-9水平，比较两组患者癌胚抗原和CA19-9水平与150例正常志愿者的检测结果的差异，并比较两组患者之间癌胚抗原和CA19-9水平的差异。结果 Ⅳ期胃癌组的癌胚抗原水平[(39.63±12.86) ng/mL]和CA19-9水平[(41.95±13.62) U/mL]明显高于健康对照组(P<0.01)，Ⅳ期胃癌腹膜转移患者组的癌胚抗原水平[(57.34±9.71) ng/mL]和CA19-9水平[(71.95±14.69 )U/mL]明显高于Ⅳ期胃癌无腹膜转移患者组(P<0.05)。肿瘤直径越大、淋巴结转移越多，癌胚抗原水平及CA19-9水平越高。结论 癌胚抗原和CA19-9联合检测可作为识别Ⅳ期胃癌有无腹膜转移及其严重性的重要指标，对Ⅳ期胃癌的诊断与估计预后有重要意义。
[关键词] 癌胚抗原；CA19-9 ；胃癌；腹膜转移
[中图分类号] R735.2 [文献标识码] B [文章编号]1673-9701(2011) 23-43-02
Value of Combination of Carcinoma Antigen and CA19-9 in Diagnosis of Ⅳ Period Gastric Cancer Peritoneal Transfer
WANG Zongli
Huzhou Municipal First People's Hospital in Zhejiang Province, Huzhou 313000 ,China
[Abstract] Objective To discuss the diagnostic value of carcinoma antigen and CA19-9 combination test in Ⅳ period of gastric cancer peritoneal transfer. Methods To measure and compare the level of CEA and CA19-9 in each group：119 gastric carcinoma with Peritoneal transfer who were hospitalized between January 2008 to January 2010，151 gastric carcinoma without peritoneal transfer who were hospitalized in the same time，150 volunteer who were health. Results The level of CEA(39.63±12.86) ng/mL and CA19-9水平(41.95±13.62 )U/mL of gastric carcinoma group were higher than the volunteer group, The level of CEA(57.34±9.71) ng/mL and CA19-9(71.95±14.69) U/mL of gastric carcinoma with peritoneal transfe)group were higher than the gastric carcinoma without Peritoneal transfer group. The bigger of Tumor diameter、The more of lymph node, the higher CEA and CA19-9 level was. Conclusion The combination test of CEA and CA19-9 helpsⅣ period gastric carcinoma Diagnosis and Antidiastole, and was of important significance in diagnosis and prognosis
[Key words] CEA；CA19-9；Gastric carcinoma；Peritoneal transfer
Ⅳ期胃癌有无腹膜转移是影响其预后的重要因素[1]。而判断有无腹膜转移一般只有在手术时取材活检才可确认，而部分患者此时已不适合手术治疗。癌抗原199 (CA199)属于肿瘤相关糖链抗原，癌胚抗原(CEA)是一种糖蛋白。它们在胃癌中均有表达[2-6]。本文探讨癌胚抗原和CA19-9联合检测在Ⅳ期胃癌有无腹膜转移诊断及临床病情评估中的作用，并比较其与正常志愿者的检测结果的差异，现报道如下。
1 资料与方法 ......
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