阿奇霉素、甲基泼尼松龙、人血丙种球蛋白治疗难治性支原体肺炎疗效观察(1)
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[摘要] 目的 探讨阿奇霉素、甲基泼尼松龙、人血丙种球蛋白治疗难治性支原体肺炎(RMPP) 的临床疗效。方法 70例难治性支原体肺炎患儿随机分成治疗组和对照组各35例，治疗组35 例RMPP患者均给予阿奇霉素静脉或口服治疗3个疗程，同时联合应用甲基泼尼松龙针、人血丙种球蛋白针，对照组35例患者仅应用阿奇霉素治疗，观察对比两组的临床疗效。结果 与对照组比较，治疗组的总有效率达90%以上，明显高于对照组71.4%，差异有显著性(P<0.05)。治疗组咳嗽消失时间、退热时间、肺部啰音消失时间及住院时间均分别短于对照组，差异有显著性(P<0.05)。 结论 足量、足疗程选用大环内脂类抗生素如阿奇霉素，同时对病情严重者早期联合应用激素、丙种球蛋白等治疗难治性支原体肺炎疗效确切，临床预后良好，值得临床推广和应用。
[关键词]难治性肺炎支原体肺炎；阿奇霉素；甲基泼尼松龙；人血丙种球蛋白
[中图分类号] R725.6；R563.1 [文献标识码] B [文章编号] 1673-9701(2011)24-68-02
Clinical Treatment Analysis on Refractory Mycoplasma Pneumoniae Pneumonia
FENG Jinyan QIAN Liwen
Pediatrics Department，Cixi City People’s Hospital，Cixi 315300，China
[Abstract] Objective To explore the azithromycin， methylprednisolone， human serum gamma globulin combination treatment refractory mycoplasma pneumoniae pneumonia(RMPP). Methods All 70 patients were randomly divided into treatment group and control group 35 cases respectly， the treatment group of 35 patients were given intravenous or oral azithromycin treatment for 3 cycles， while the combination of methylprednisolone needle， people gamma globulin needle， the control group of 35 patients applied only azithromycin， and to compare the two groups clinical efficacy. Results Compared with the control group，the total effective rate of treatment group was 90% above，significantly higher than 71.4% (P<0.05). Cough treatment group lost time， cooling time， pulmonary rales disappeared all the time and hospital stay of the treatment group were shorter than the control group(P<0.05). Conclusion Earlily diagnose and treat，full dosage and enough course of treatment with Macrolide antibiotics，united with hormone and gamma globulin to aim directly at severe patients，and strengthened combined therapy.
[Key words] Refractoriness mycoplasma pneumoniae pneumonia；Azithromycin；Methylprednisolone；Human gamma globulin
近几年儿童难治性肺炎支原体肺炎(refractory mycoplasma pneumoniae pneumonia，RMPP)有逐年增加的趋势[1]，由于儿童处于发育期，许多抗生素如四环素、喹诺酮类、氨基糖苷类药物的使用受到一定的限制 。我院2006 年1月～2010年6月应用阿奇霉素、甲基泼尼松龙、人血丙种球蛋白联合治疗35 例RMPP 患儿，并对其疗效进行观察，旨在提高对RMPP的诊治水平，现报道如下。
1 资料与方法
1.1 一般资料 ......
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