普米克令舒等三联雾化吸入辅助治疗儿童支原体肺炎(1)
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[摘要] 目的 观察普米克令舒等三联雾化吸入辅助治疗儿童肺炎支原体肺炎的疗效。方法 将100例肺炎支原体肺炎患儿随机分成两组：治疗组50例，在常规静脉用阿奇霉素针的基础上加普米克令舒等三联雾化吸入；对照组50 例，单用阿奇霉素针静脉治疗；用药后观察疗效、症状体征、IL-4、不良反应等指标。结果治疗组疗效优于对照组(P＝0.027)；治疗组临床症状消失时间及胸片恢复时间较对照组显著缩短(P<0.01)，治疗组3个月后血清IL-4水平明显低于对照组(P<0.01)。结论 普米克令舒等三联雾化吸入辅助治疗儿童肺炎支原体感染疗效优于单纯抗炎治疗。
[关键词] 支原体肺炎；普米克令舒；爱全乐；特布他林；雾化吸入
[中图分类号] R725.6[文献标识码] B[文章编号] 1673-9701(2011)27-76-02
Pulmicort Respules Trigeminy Atomization Inhalation in Adjuvant Therapy of Children Mycoplasma Pneumonia
FENG Jinyan
Pediatric Department in People’s Hospital of Cixi City，Cixi 315300，China
[Abstract] Objective To observe the curative effect of pulmicort respules trigeminy atomization inhalation treating the disease of children mycoplasma pneumonia. Methods All 100 cases with mycoplasma pneumonia were randomly divided into two groups，such as treatment group(50 cases) with intravenous injection of azithromycin adding pulmicort respules trigeminy atomization inhalation and control group(50 cases) only with azithromycin intravenous injection. Then we observed curative effect，symptoms，signs，IL-4 and adverse effect between the two groups after medication. Results The curative effect in the treatment group was much better than the control group(P=0.027). The treatment group’s extinction time of clinical symptoms-signs and sternum recovery time were much shorter than the control group(P<0.01). And IL-4 level in the treatment group after 3 months was much lower than the control group(P<0.01). Conclusion The curative effect of pulmicort respules trigeminy atomization inhalation treating children mycoplasma pneumonia was much better than the effect of only with antiinflammatory treatment method.
[Key words] Mycoplasma pneumonia(MP)；Pulmicort respules；Atrovent；Terbutaline；Atomization inhalation
近十年来，肺炎支原体(MP)对人类的致病作用逐步得到重视，MP感染发病率文献报道不一，因研究对象、季节、诊断方法与标准不同而异。目前绝大多数文献报道的是对来医院就诊的呼吸道感染患儿的实验室调查结果，并非基于社区儿童的前瞻性调查。亚洲多中心研究结果显示[1]，CAP 患者中 MP 双份血清抗体阳性占 12.2%，单份血清持续高 MP-IgM滴度占 10.2%，学龄儿童更高。有证据表明，MP感染与哮喘发生密切相关[2，3]。我科在用阿奇霉素抗感染及止咳、化痰等对症治疗的同时，采用普米克令舒和特布他林、爱全乐三联雾化吸入治疗肺炎支原体肺炎50例，疗效满意，现报道如下。
1资料与方法
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