灯盏花素对HIE患儿血清hs-CRP和sICAM-1的影响及疗效机制(1)
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[摘要] 目的 探讨灯盏花素对新生儿缺氧缺血性脑病患儿的临床疗效及其对HIE患儿血清C反应蛋白和sICAM-1的影响机制，以期为临床工作提供理论支持。方法 选择2009年1月～2010年1月56例在我院确诊为新生儿缺氧缺血性脑病患儿作为研究对象，按患儿的入院顺序随机分为观察组和对照组各28例，对照组予常规治疗，观察组在对照组常规治疗的基础上加用灯盏花素，同时检测治疗前、治疗后两组患儿血清中hs-CRP和sICAM-1的含量变化，并应用统计学方法进行比较分析。结果 观察组患儿治疗后的总有效率明显高于对照组，观察组患儿治疗后血清中hs-CRP、sICAM-1均较治疗前明显降低，且观察组较对照组降低更明显，两组差异有统计学意义(P<0.05)。结论 在常规治疗的基础上联合灯盏花素治疗新生儿缺氧缺血性脑病具有较好的疗效，且能下调患儿血清中的hs-CRP、sICAM-1的含量，减轻或者抑制由二者引发的炎症反应。
[关键词] 新生儿缺氧缺血性脑病；灯盏花素；C反应蛋白；sICAM-1
[中图分类号] R272；R722.1 [文献标识码] B [文章编号] 1673-9701(2011)32-46-02
The Effect of Breviscapine on Serum High-sensitivity CRP and sICAM-1 in HIE Children and Its Mechanism of Efficacy
WANG Cong
The Maternal and Child Care Service Centre of Cixi City, Cixi 315300, China
[Abstract] Objective To investigate the clinical efficacy of Breviscapine on neonatal hypoxic ischemic encephalopathy, and its impact mechanism on serum C-reactive protein and sICAM-1 in children with HIE in order to provide theoretical support for clinical work. Methods Fifty-six cases of children diagnosed neonatal hypoxic ischemic encephalopathy in our hospital from January 2009 to January 2010 were choosed as research subjects and randomly divided into two groups according to the admission of hospital with 28 patients in each group. The control group received conventional treatment and the observation group received conventional therapy plus Breviscapine, while testing before treatment, after treatment in both groups serum hs-CRP levels and hypersensitivity sICAM-1 changes, and application of statistical methods for comparative analysis. Results The overall response after treatment was significantly higher efficiency in the observation group after treatment in children with hypersensitivity of serum hs-CRP, sICAM-1 after treatment than before treatment was significantly lower than in the control group and observation group reduce the more obvious difference between two groups was statistically significant (P<0.05). Conclusion In conventional therapy based on the joint Breviscapine treatment of neonatal hypoxic ischemic encephalopathy with good effect, and can lower the serum hs-CRP and sICAM-1 levels, reduce or inhibit the inflammatory response induced by both ......
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