C反应蛋白在儿童溃疡性结肠炎患者疗效和预后中的作用(1)
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[摘要] 目的 检测儿童UC患者中的C反应蛋白水平并观察在疾病的临床治疗效果及对其预后评估中的作用。方法 收集来我院进行治疗的处于活动期的儿童UC患者29例，缓解期患儿16例，同时选取健康体检儿童30名作为对照，三组研究对象均取血清标本进行CRP浓度的检测。结果 活动期、缓解期、健康者不同性别间的CRP差异没有显著性。与缓解期及其健康者CRP浓度比较，活动期明显较高，差异均具有显著性(P<0.05)；缓解期和健康者平均值之间无显著性差异。治疗后和治疗前的CRP浓度平均值比较均明显降低，差异均具有统计学意义(P<0.05)。结论 在活动性儿童UC患者中，CRP浓度明显较高，其能够对疾病的治疗效果及其预后起到判断作用。
[关键词] 儿童溃疡性结肠炎；C反应蛋白；检测；预后评估
[中图分类号] R574.6 [文献标识码] B [文章编号] 1673-9701(2011)34-49-02
The Efficacy and Prognosis of C-reactive Protein in Patients with Ulcerative Colitis in Children
XIANG Juanfen
Department of Pediatrics，Zhejiang Province Longquan City Hospital of TCM， Longquan 323700，China
[Abstract] Objective To determine the C-reactive protein levels in the children with UC patients and observe the clinical effect of the disease and its prognostic role. Methods All 29 cases in our hospital were active UC patients，16 cases were in remission，while 30 cases selected healthy children as controls，three groups of children were serum concentrations of CRP testing specimens. Results There were no significant difference in CRP levels among activity，remission，healthy patients. Compared CRP of remission and healthy subjects，activity subjects was significantly higher，the differences were significant(P<0.05). Remission and healthy controls were no significant difference. The average CRP levels before treatment and after treatment were significantly lower，the differences were statistically significant(P<0.05). Conclusion In children with active children with UC，CRP concentration was significantly higher，it can effect on the treatment and prognosis of the disease to determine the role play.
[Key words] Children with ulcerative colitis；C-reactive protein；Detection；Prognosis
溃疡性结肠炎(ulcerative colitis，UC)和克罗恩病都属于炎症性肠病，在我国近几年其发病率明显有升高的趋势。导致炎症性肠病发生的原因及其发病机制比较复杂，至今仍然没有阐释清楚。现在临床上对炎症性肠病的诊断和对于疾病预后的判断采用多种方法，如使用生化指标检测来判定，用内镜下黏膜修复或者采用组织病理学分级等方法进行判定，但以上这些方法对于疾病发展处于何种状态均不能及时有效的反映出来[1]。目前临床上已经使用C反应蛋白(CRP)作为炎症性肠病诊断和预测疾病发展的一个重要指标，只是在儿童UC等疾病中具有较少的报道。本研究分别选取了处于活动期的UC患儿、缓解期患儿及健康儿童，对其CRP浓度进行检测，观察这一指标在疾病的临床疗效和预后评估中的作用。
1 对象与方法
1.1 研究对象
病例收集为2005年3月～2011年3月来我院就诊的45例溃疡性结肠炎患儿，其中男性27例，女性18例，经过对患者临床症状及体征进行观察，结合消化道钡餐造影、电子结肠镜检查结果及其患者的病理组织学检查确诊 ......
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