木糖醇注射液稀释泮托拉唑钠治疗消化性溃疡临床观察(1)
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[摘要] 目的 探讨木糖醇注射液稀释泮托拉唑钠治疗消化性溃疡的可行性与临床疗效。方法 选取消化性溃疡患者120例，随机分为观察组和对照组各60例。观察组用木糖醇注射液稀释泮托拉唑钠，对照组用0.9%氯化钠注射液稀释。观察两组患者的临床疗效、用药时间与不良反应。结果 观察组与对照组临床总有效率分别为98.33%、96.67%，用药时间分别为(9.3±1.6)d，(9.6±1.8)d，不良反应发生率均为3.33%，两组上述各指标比较，均无统计学差异(P>0.05)。结论 木糖醇注射液可用于稀释泮托拉唑钠治疗消化性溃疡，但应控制速度，缓慢静脉滴注。
[关键词] 木糖醇注射液；泮托拉唑钠；消化性溃疡
[中图分类号] R573.1 [文献标识码] B [文章编号] 1673-9701(2011)34-67-02
Treating Peptic Ulcer by Pantoprazole Sodium Diluted by Xylitol Injection
XU Wanfen
Zhejiang Province Taizhou City Luqiao District the Second People's Hospital，Taizhou 318058，China
[Abstract] Objective To explore the feasibility and clinical effect of treating peptic ulcer by pantoprazole sodium diluted by Xylitol injection. Methods Selecting 120 patients with peptic ulcer, and they were divided into observation group and control group randomly with 60 cases in each. Patients in observation group were given pantoprazole sodium with Xylitol injection, and patients in control group were given pantoprazole sodium with 0.9% sodium chloride injection. Comparing clinical efficacy, medication time and adverse reaction in 2 groups after treatment. Results The clinical total effective rate of observation group and control group were 98.33% and 96.67%, medication time were (9.3±1.6)d and (9.6±1.8)d respectively, and the adverse reactions incidence were both 3.33%, and there were no statistical difference (P>0.05). Conclusion Xylitol injection can be used for dilution of pantoprazole sodium in the treatment of peptic ulcer, but should control the speed, and slow intravenous infusion is advised.
[Key words] Xylitol injection；Pantoprazole sodium, Peptic ulcer
木糖醇(Xylitol)是一种五碳糖醇，理化稳定性好，易溶于水，在体内直接透过细胞膜，不需要依赖胰岛素直接参与糖代谢[1]。因此，作为一种新型的输液制剂，木糖醇注射液被用于替代葡萄糖注射液或生理盐水，与某些药物配伍应用于疾病的治疗[2]。目前，尚未见木糖醇注射液与泮托拉唑钠配伍应用的临床报道。在动物实验的基础上，笔者将木糖醇注射液稀释泮托拉唑钠用于治疗消化性溃疡(peptic ulcer，PU)，取得了与0.9%氯化钠注射液稀释治疗类似的效果，现报道如下。
1 资料与方法
1.1 临床资料
随机选取2009年1月~ 2010年12月在我科治疗的消化性溃疡(PU)患者120例，临床症状与胃镜检查结果均符合PU的诊断标准[3]，且均为活动期PU，排除恶性溃疡。随机将120例PU患者分为观察组和对照组 各60例。观察组中男37例，女23例；年龄31～73岁，平均(52.5±9.6)岁；病史2个月～16年，平均(5.0±2.1)年；其中胃溃疡16例，十二指肠溃疡21例，复合性溃疡23例；溃疡直径<1.0cm者18例 ......
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