血浆抵抗素与人类肥胖、胰岛素抵抗的相关性研究(1)
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[摘要] 目的 探讨血浆抵抗素水平与人类肥胖、胰岛素抵抗的关系。方法 检测80例2型糖尿病患者(T2DM组)和80例糖耐量正常者(对照组)的外周血抵抗素度，比较两组间的差异。分析抵抗素与体重指数(BMI)、腰臀比(WHR)和胰岛素抵抗性的相关性。结果 T2DM组和对照组血浆抵抗素水平分别为(10.2±5.0)ng/mL和(6.4±2.3)ng/mL，T2DM组显著高于对照组(P<0.01)。抵抗素与BMI、WHR无显著相关性(P>0.05)，而与HOMA-IR呈正相关性(r=0.25，P<0.05)。结论 2型糖尿病患者血浆抵抗素水平升高，抵抗素与胰岛素抵抗相关。
[关键词] 人血浆抵抗素；肥胖；胰岛素抵抗
[中图分类号] R589.2 [文献标识码] B [文章编号] 1673-9701(2011)35-70-02
The Measurement of Plasma Resistin and Its Correlative Analysis with Obesity and Insulin Resistance
FEI Meijiao
Department of Endocrinology, the First People's Hospital of Xiaoshan District Hangzhou City in Zhejiang Province, Hangzhou 311200, China
[Abstract] Objective To discuss the relationship of resistin with obesity and insulin resistance. Methods All 80 type 2 diabetes mellitus patients (T2DM group) and 80 subjects with normal glucose tolerance from normal physical examination(control group). Each detection peripheral resistance element degrees, comparing the difference between two groups. Analysis with BMI, WHR resistance element and insulin resistance sexual correlation. Results High-risk T2DM group and control group plasma resistance element level which were (10.2±5.0) ng/ mL and (6.4±2.3) ng/mL, Significantly higher than the control group in high-risk T2DM group(P<0.01). Resistance element and BMI, WHR were no significant correlation(P>0.05), but with homair of parturients(r=0.25，P<0.05). Conclusion In patients with type 2 diabetes plasma resistance element leels, resist grain and insulin resistance related.
[Key Words] Resistin; Obesity; Insulin resistance
Resistin是2001年Steppan等[1]首次报道的一种多肽类激素。啮齿动物中，resistin是由脂肪组织特异分泌，与胰岛素抵抗关系密切，被认为是联系肥胖与2型糖尿病的重要纽带[1]。人类的resistin主要由外周血单核细胞表达，人类的resistin基因及其表达产物的结构与啮齿动物的存在差异[2]。人类的resistin的抵抗素的生物作用尚不清楚，本研究探讨人血浆抵抗素水平与肥胖、胰岛素抵抗(IR)的关系。
1 对象与方法
2010年1月～12月在我院收治的80例2型糖尿病患者(T2DM组)和同期来我院体检的80例糖耐量正常者(对照组)纳入本研究。所有受试者均常规询问病史和体检，测量身高、体重、腰围、臀围、计算体重指数(BMI)和腰臀比(WHR)。取空腹血，测血浆resistin水平(采用美国Phoenix Pharmaceuticals.Inc的酶联免疫分析法试剂盒检测)，测空腹血糖(FBG)和胰岛素(FIns)的浓度，应用稳态模型评估法(homeostasis model assessment ......
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