三七总皂苷对脊髓损伤大鼠斜板实验评分的影响(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 探讨三七总皂苷对脊髓损伤大鼠行为学变化的影响。 方法 采用改良的Allen’s法将80只成年雌性Wistar大鼠造成脊髓中度损伤模型，随机分为两组：脊髓损伤+生理盐水组(对照组)、脊髓损伤+三七总皂苷组(实验组)，每组40只。以损伤后1、3、5、7、14 d作为观察时间点，在每个时间点各组随机选择8只大鼠行斜板实验评分。 结果 实验组大鼠斜板实验评分均明显优于对照组，两组间差异有统计学意义(P<0.05)。 结论 三七总皂苷可减轻脊髓损伤后继发性损害。
[关键词] 三七总皂苷；脊髓损伤；影响
[中图分类号] R285.5 [文献标识码] B [文章编号] 1673-9701(2012)01-009-02
The influence of Panax notoginsenosides on the sloping plate experiment score in rats with spinal cord injury
ZHANG Guoping1 ZHANG Huanhu2 ZHANG Weidong3
1.Department of Orthopedics, the Second Hospital of Shanxi Medical University，Taiyuan 030001, China; 2.Department of TCM, the Second Hospital of Shanxi Medical University，Taiyuan 030001, China; 3.Department of Orthopedics, the People's Hospital of Lvliang City in Shanxi Province, Lvliang 033000, China
[Abstract] Objective To investigate the influences of Panax notoginsenosides on behaviors of the rats with spinal cord injuriy. Methods By using the improved Allen's method to divide eighty models of adult female Wistar rats with moderate damage in spinal cord. The rats were randomly divided into two groups: one group was spinal cord injury + normal saline (control group), and the other group was spinal cord injury + Panax notoginsenosides (experimental group). Each group had forty rats. 1 d, 3 d, 5 d, 7 d, 14 d after the injury were chosen as the observation time points. At each time point 8 rats were randomly selected from each group for conducting sloping plate experiment. Results The scores of the experimental group were significantly better than those of the control group. The differences between the two groups were statistically significant (P<0.05). Conclusion The Panax notoginsenosides can relieve the secondary damage after spinal cord injury.
[Key words] Panax notoginsenosides; Spinal cord injury; Influence
脊髓损伤(spinal cord injury，SCI)年发病率为(20～40)/100万[1]，因脊髓损伤造成的劳动能力丧失、生活不能自理、严重并发症等问题日益困扰着整个社会。三七总皂苷(total saponins of Panax Notoginseng，TSPN)是从我国传统珍贵药材三七中提取出来的主要药理成分，主要由人参皂苷Rg1、Rb1和三七皂苷R1、R2等40多种皂苷组成 ......
您现在查看是摘要介绍页，详见PDF附件(1774kb)。