逍遥散联合草酸艾司西肽普兰片治疗抑郁症疗效观察(1)
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[摘要] 目的 观察逍遥散加减配合草酸艾司西肽普兰片治疗抑郁症的临床疗效。 方法 收集抑郁症病例72例，随机分为两组。研究组36例，用逍遥散联合草酸艾司西酞普兰片治疗；对照组36例，单纯用草酸艾司西肽普兰片治疗。 结果 研究组总临床治疗有效率与对照组差异无统计学意义(P>0.05)，但是在第6周研究组患者HAMD评分明显低于对照组，比较差异有统计学意义(P<0.05)。研究组与对照组的不良反应方面比较，差异有高度统计学意义(P<0.01)。 结论 逍遥散联合草酸艾司西肽普兰治疗抑郁症具有疗效好，不良反应少的特点。
[关键词] 抑郁症；逍遥散；草酸艾司西肽普兰片；不良反应
[中图分类号] R286 [文献标识码] B [文章编号] 1673-9701(2012)01-066-02
Xiaoyao powder combined with escitalopram oxalate tablets in the treatment of depression
GAO Xiang
Department of Psychiatry, Yongzhou Zhishan Hospital of Hunan Province, Yongzhou 425113, China
[Abstract] Objective To observe the Xiaoyao powder combined with escitalopram oralate tablet on treatment of depression. Methods All of 72 cases of depression, were randomly divided into two groups. The study group 36 cases, was treated by Xiaoyao powder combined escitalopram oxalate tablets; The control group, was given Oxalic acid esmolol Copeland tablets. Results The study group of the total efficiency of clinical treatment and control group had no significant difference (P>0.05), but the study group at the end of the sixth week HAMD scores were significantly less than that in the control group, and the difference was significant, with statistical significance (P<0.05). Study group and the control group the ADR of comparison, there were significant differences statistically significant (P<0.01). Conclusion Xiaoyao Powder Combined with Escitalopram oxalate tablet in treatment of depression has good curative effect, less adverse reaction.
[Key words] Depression; Xiaoyao powder; Escitalopram oxalate tablet; Adverse reaction
抑郁症(Depression)是主要表现为情绪低落、兴趣减低、悲观、思维迟缓、缺乏主动性、饮食差、睡眠差的一种精神疾患，患者总怀疑自己患有各种疾病，严重者可出现自杀念头和行为。近年来，随着现代社会节奏的加快和竞争加大以及精神压力的增加，抑郁症的发病率不断上升，以致它被称为精神病学中的“感冒”。抑郁症目前已成为中国乃至全球疾病中给人们造成严重负担的第二位重要疾病，对患者及其家属造成巨大的痛苦和损失。抑郁症属于中医学“郁证”、“失眠”等范畴。目前对于抑郁症的治疗缺乏有效的方法和特效的药物，中医药治疗抑郁症历史悠久，具有较好的效果，不良反应比西药比较低，且大多数患者容易接受中医药的治疗[1]。为此，本文采用逍遥散联合5-羟色胺再摄取抑制剂草酸艾司西酞普兰片对抑郁症患者进行治疗，对中药逍遥散合并西药治疗抑郁症患者进行了临床对照研究，现将结果报道如下。
1 资料与方法
1.1 一般资料
72例抑郁症患者选自2007年6月～2011年6月在我院门诊治疗的患者。入选标准为：(1)符合《中国精神障碍分类与诊断标准》第3版(CCMD-3)抑郁症诊断标准[2]；(2)汉密尔顿抑郁量表(HAMD)17项总分≥18分[3]，中医辨证均为抑郁证的肝气郁结型。排除标准为：(1)有药物过敏史 ......
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