谷氨酰胺强化肠内营养对颅脑损伤患者的临床效果观察(1)
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[摘要] 目的 探讨谷氨酰胺强化肠内营养制剂对颅脑损伤患者的临床效果。 方法 将我院64名颅脑损伤患者分为Gln强化组和常规EN组，每组34例。比较两组患者营养支持前及支持后14 d营养指标及相关并发症发生情况。 结果 Gln强化组各项营养指标均高于常规EN组，预后好于常规EN组，感染并发症的发生均少于常规EN组。 结论 谷氨酰胺强化型肠内营养治疗可增强颅脑损伤患者营养治疗的效果，减少与肠内营养有关的并发症及降低颅脑损伤患者感染率和死亡率，改善患者的预后。[关键词] 谷氨酰胺；颅脑损伤[中图分类号] R651.1；R459.3
[文献标识码] B
[文章编号] 1673—9701(2012)23—0150—02Clinical effect of glutamine enhanced enteral nutrition on patients with severe craniocerebral injuryCHEN Dan
YU Xia
FENG QihuiDepartment of Pharmacy， Yanqi Hospital， the Second Division of Xinjiang Production and Construction Corps， Yanqi 841100， China[Abstract] Objective To evaluate the influence of glutamine (Gln) enriched enteral nutrition (EN) on patients under severe brain injuries. Methods Sixty—four patients with severe brain injury were randomly divided into the experimental group and the control group， and each group had 34 patients. Nutrition indicators and related complications between two groups after 14 days and changes were evaluated. Results At the end of the experiment， levels of each nutrition indicators of the experimental group were higher than the control group with significant differences. Levels of related complications of the experimental group were lower than those of the control group with significant differences. Conclusion Glutamine enriched nutrition can effectively improve the prognosis of patients with severe brain injury.[Key words] Glutamine； Severe brain injury颅脑损伤患者多存在营养风险(nutritional risk)，其营养不良发生率较高[1]。早期肠内营养(enteral nutrition，EN)非常重要[2]。谷氨酰胺(Gln)是人体重要的具有特殊营养作用的条件必需氨基酸，肠内营养制剂中加Gln可增强患者的免疫防御系统[3]，改善患者的预后。因此我院对68例颅脑损伤应用谷氨酰胺强化肠内营养制剂的临床效果进行初步探讨，现报道如下。1 资料与方法1.1 临床资料选择2010年11月～2011年10月我院脑外科收治的颅脑损伤(4≤格拉斯格评分≤12分)68例，其中男50例，女18例，年龄43～71岁，平均(53.71±7.12)岁。所有入选患者均满足：①头颅CT检查及临床证实为颅脑损伤伴意识障碍；②胃肠道功能正常并能实施鼻饲肠内营养；③根据营养风险筛查2002(NRS 2002)[4] ......
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