血清2—MG与LDH对非霍奇金淋巴瘤治疗效果的判断价值(1)
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[摘要] 目的 探讨血清β2微球蛋白(β2—MG)与乳酸脱氢酶(LDH)与非霍奇金淋巴瘤临床特征及预后的关系及临床意义。 方法 62例非霍奇金淋巴瘤患者，按临床症状分为A、B组，按骨髓涂片分为淋白组、骨髓浸润组及无骨髓浸润组，比较各组及不同预后血清β2—MG与LDH水平。 结果 不同临床分期血清β2—MG与LDH水平之间比较差异有统计学意义(P < 0.01)；B组血清β2—MG与LDH水平显著高于A组(P < 0.01)。淋白组、骨髓浸润组及无骨髓浸润组血清β2—MG、LDH水平差异显著(P < 0.01)。治疗前后不同疗效组之间血清β2—MG、LDH水平差异显著，治疗后CR组、PR组血清β2—MG、LDH水平较治疗前显著降低(P < 0.01)。血清β2—MG、LDH 的ROC曲线下面积分别为0.911、0.924(P < 0.05)。 结论 血清β2—MG和LDH与非霍奇金淋巴瘤临床症状、临床分期、骨髓浸润及疗效密切相关，可作为判断疗效的临床指标。
[关键词] 非霍奇金淋巴瘤；β2微球蛋白；L—乳酸脱氢酶
[中图分类号] R733.1 [文献标识码] B [文章编号] 1673—9701(2012)25—0030—03
The value of serum β2—MG and LDH in judging non—Hodgkin's lymphoma treatment
WU Ningning
Department of Hematology，the Second Hospital of Ningbo City，Ningbo 315000，China
[Abstract] Objective To explore the relationship of serum β2—microglobulin (β2—MG) and lactate dehydrogenase (LDH) and the clinical features and prognosis of non—Hodgkin's lymphoma. Methods All 62 cases of non—Hodgkin's lymphoma patients， according to the clinical symptoms were divided into A， B groups， according to bone marrow smears were divided into a shower of white group， bone marrow infiltration and without bone marrow infiltration group. Each group were compared and the different prognosis of serum β2—MG and LDH levels. Results The differences of serum β2—MG and LDH level between the different clinical stages were significant (P < 0.01)； serum β2—MG， and LDH levels of group B were significantly higher than group A (P < 0.01). The serum β2—MG， LDH level among cream white group， bone marrow infiltration group and no bone marrow infiltration were significantly different (P < 0 ......
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