左氧氟沙星替代标准三联中的克拉霉素治疗幽门螺杆菌感染93例(1)
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[摘要] 目的 探讨左氧氟沙星替代标准三联中的克拉霉素治疗幽门螺杆菌感染的疗效。 方法 选取2008年3月～2011年4月在我院就诊经胃镜检查并经尿素酶法测出Hp阳性患者182例，随机分为两组，治疗组93例，对照组89例，治疗组用奥美拉唑、阿莫西林、左氧氟沙星，对照组用奥美拉唑、阿莫西林、克拉霉素，观察两组治疗效果及不良反应。 结果 治疗组93例有84例幽门螺杆菌转阴，根除率90.3%，对照组89例有66例幽门螺杆菌转阴，根除率74.2%，差异有统计学意义(P < 0.05)。 结论 应用左氧氟沙星替代目前国内推荐的标准三联中的克拉霉素治疗幽门螺杆菌感染根除率较高，值得临床推广应用。
[关键词] 左氧氟沙星；幽门螺杆菌；克拉霉素
[中图分类号] R573.1 [文献标识码] B [文章编号] 1673—9701(2012)26—0151—02
Levofloxacin in place of clarithromycin in standard triple therapy for the treatment of Hp： A study of 93 cases
HUANG Baogen LONG Linyu
Department of Medicine， Ji’an County People’s Hospital in Jiangxi Province， Ji’an 343100， China
[Abstract] Objective To investigate the effect of levofloxacin in place of clarithromycin in standard triple therapy (omeprazole， amoxicillin and clarithromycin) for the treatment of Helicobacter pylori (Hp). Methods All of 182 patients were sampled from Hospital， whose Hp registered positive after gastroscopy and urease test. They were randomly divided into two groups： treatment group with 93 patients and the control group with 89 cases. Omeprazole， amoxicillin and levofloxacin were combined in treatment group， whereas omeprazole， amoxicillin and clarithromycin were used in control group. Results The eradication rates of Hp in the treatment group and control group were respectively 90.3% and 74.2%， there were statistically significant differences (P < 0.05). Conclusion The application of levofloxacin in place of clarithromycin in standard triple therapy (omeprazole， amoxicillin and clarithromycin) for the treatment of Hp demonstrated better eradication rate， and therefore it was favorably advisable in clinical practice.
[Key words] Levofloxacin； Helicobacter pylori； Clarithromycin ......
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