颈动脉粥样硬化与脑梗死合并糖尿病发生率的相关性研究(1)
[摘要] 目的 探讨颈动脉粥样硬化与脑梗死合并2型糖尿病之间的关系。 方法 收集我院2011年1月～2013年1月共283例确诊2型糖尿病的患者纳入实验，将合并脑梗死的143例患者作为观察组，其余单纯2型糖尿病患者140例作为对照组，对两组的生化指标，包括C反应蛋白(CRP)、同型半胱氨酸(HCY)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、纤维蛋白原进行对比分析，对所有入选病例进行颈动脉彩超检查，明确颈动脉粥样硬化斑块形成情况。 结果 观察组CRP、HCY、TC、LDL水平较对照组显著升高，HDL水平较对照组降低(P<0.05)，观察组颈动脉狭窄程度、狭窄的血管数量均明显多于对照组(P<0.05)，观察组斑块数量更多，且不稳定型斑块多于对照组(P<0.05)。 结论 颈动脉粥样硬化与脑梗死合并2型糖尿病有明显相关性。
[关键词] 颈动脉粥样硬化；脑梗死；2型糖尿病
[中图分类号] R544.1；R587.1 [文献标识码] B [文章编号] 1673-9701(2015)26-0027-04
The relationship of carotid atherosclerosis and the incidence of cerebral infarction associated with type 2 diabetes
AI Yaqin
Department of Endocrinology， the Fourth Affiliated Hospital of Nanchang University， Nanchang 330003， China
[Abstract] Objective To investigate the relationship of carotid atherosclerosis and the incidence of cerebral infarction associated with type 2 diabetes. Methods A total of 283 patients with type 2 diabetes from January 2011 to January 2013 in our hospital were divided into two groups. 143 patients associated with the cerebral infarction were regarded as the observation group while other 140 cases regard as the control group. The biochemical indicators including C-reactive protein， homocysteine triglyceride， total cholesterol， high density lipoprotein， low-density lipoprotein and fibrinogen of two groups were compared. At the same time， all patients were accepted the Color Doppler ultrasound examination to clarify formation of plaque. Results The CRP， HCY， TC， LDL levels of observation group were significantly higher than those of the control group， while the HDL level of observation group was lower than that of the control group(P<0.05). The degree and the numbers of artery stenosis in observation group were significantly more than the control group(P<0.05). The plaque and the unstable plaque of observation group was statistically significant more than that of the control group(P<0.05). Conclusion Carotid atherosclerosis has a significant correlation with the incidence of cerebral infarction with type 2 diabetes.
[Key words] Carotid atherosclerosis； Cerebral infarction； Type 2 diabetes
在经济快速增长、生活水平快速进步、老龄化加剧的社会环境下，脑梗死已经成为多发病及常见病，并严重危害人们的健康，尤其是中老年患者。尽管脑梗死的诊疗技术不断进步，但患病人群的死亡率、致残率仍然处在明显的上升趋势中[1，2]。除此之外，呈明显上升趋势的还有2型糖尿病，据统计仅我国2型糖尿病患病人群就已经达到4500万。有研究表明[3]，2型糖尿病患者相对于非糖尿病患者不但发生脑血管病几率更高，而且发病年龄也趋近于年轻化，可能是2型糖尿病患者极易出现动脉粥样硬化，加速心脑血管疾病进展。目前有研究认为[4]观察颈动脉是否存在斑块及斑块状态可在某种程度上反映心脑血管动脉粥样硬化总体进程，且颈动脉粥样硬化、斑块形成及斑块的继发改变是发生脑梗死的重要危险因素。因此对颈动脉粥样硬化及斑块与脑梗死合并2型糖尿病的相关性进行研究具有一定的临床价值。本研究通过回顾性分析，比较了在我院就诊的143例脑梗死合并2型糖尿病和140例单纯2型糖尿病患者颈动脉斑块数量及性质并发现其中的相关性，以期为2型糖尿病患者预防脑梗死的发生起到一定的指导作用。, http://www.100md.com(艾雅琴)
[关键词] 颈动脉粥样硬化；脑梗死；2型糖尿病
[中图分类号] R544.1；R587.1 [文献标识码] B [文章编号] 1673-9701(2015)26-0027-04
The relationship of carotid atherosclerosis and the incidence of cerebral infarction associated with type 2 diabetes
AI Yaqin
Department of Endocrinology， the Fourth Affiliated Hospital of Nanchang University， Nanchang 330003， China
[Abstract] Objective To investigate the relationship of carotid atherosclerosis and the incidence of cerebral infarction associated with type 2 diabetes. Methods A total of 283 patients with type 2 diabetes from January 2011 to January 2013 in our hospital were divided into two groups. 143 patients associated with the cerebral infarction were regarded as the observation group while other 140 cases regard as the control group. The biochemical indicators including C-reactive protein， homocysteine triglyceride， total cholesterol， high density lipoprotein， low-density lipoprotein and fibrinogen of two groups were compared. At the same time， all patients were accepted the Color Doppler ultrasound examination to clarify formation of plaque. Results The CRP， HCY， TC， LDL levels of observation group were significantly higher than those of the control group， while the HDL level of observation group was lower than that of the control group(P<0.05). The degree and the numbers of artery stenosis in observation group were significantly more than the control group(P<0.05). The plaque and the unstable plaque of observation group was statistically significant more than that of the control group(P<0.05). Conclusion Carotid atherosclerosis has a significant correlation with the incidence of cerebral infarction with type 2 diabetes.
[Key words] Carotid atherosclerosis； Cerebral infarction； Type 2 diabetes
在经济快速增长、生活水平快速进步、老龄化加剧的社会环境下，脑梗死已经成为多发病及常见病，并严重危害人们的健康，尤其是中老年患者。尽管脑梗死的诊疗技术不断进步，但患病人群的死亡率、致残率仍然处在明显的上升趋势中[1，2]。除此之外，呈明显上升趋势的还有2型糖尿病，据统计仅我国2型糖尿病患病人群就已经达到4500万。有研究表明[3]，2型糖尿病患者相对于非糖尿病患者不但发生脑血管病几率更高，而且发病年龄也趋近于年轻化，可能是2型糖尿病患者极易出现动脉粥样硬化，加速心脑血管疾病进展。目前有研究认为[4]观察颈动脉是否存在斑块及斑块状态可在某种程度上反映心脑血管动脉粥样硬化总体进程，且颈动脉粥样硬化、斑块形成及斑块的继发改变是发生脑梗死的重要危险因素。因此对颈动脉粥样硬化及斑块与脑梗死合并2型糖尿病的相关性进行研究具有一定的临床价值。本研究通过回顾性分析，比较了在我院就诊的143例脑梗死合并2型糖尿病和140例单纯2型糖尿病患者颈动脉斑块数量及性质并发现其中的相关性，以期为2型糖尿病患者预防脑梗死的发生起到一定的指导作用。, http://www.100md.com(艾雅琴)