少腹逐瘀汤治疗腹股沟疝术后慢性疼痛32例临床观察(1)
[摘要] 目的 探讨少腹逐瘀汤治疗腹股沟疝术后慢性疼痛的临床疗效。 方法 选择2008年10月～2014年9月期间收治的64例腹股沟疝无张力修补术后慢性疼痛患者，按随机数字法分成治疗组32例和对照组32例。治疗组给予少腹逐瘀汤口服治疗，对照组给予塞来昔布口服治疗，观察并比较两组的视觉模拟评分(visual analogue scale，VAS)、卡洛连舒适度评分(carolinas comfort scale，CCS)、白介素6(IL-6)以及两组的治疗效果。结果 治疗组总有效率明显高于对照组，差异有统计学意义(P<0.05)；治疗后治疗组的VAS明显低于对照组，差异有统计学意义(P<0.05)。治疗后治疗组的CCS明显低于对照组，差异有统计学意义(P<0.05)。与对照组比较，治疗组外周血IL-6水平明显降低，差异有统计学意义(P<0.05)。 结论 少腹逐瘀汤治疗腹股沟疝术后慢性疼痛效果明显，可以显著提高患者的生活质量，其作用机制可能与减轻炎症反应而发挥止痛效应有关。
[关键词] 少腹逐瘀汤；腹股沟疝；无张力疝修补术；慢性疼痛
[中图分类号] R656.2 [文献标识码] B [文章编号] 1673-9701(2015)31-0103-04
Clinical observations on Shaofuzhuyu decoction in treating 32 cases of chronic pain after repair of inguinal hernia
YANG Ying1 ZHANG Zhe2
1.Department of Occupational Disease， Hangzhou Occupational Disease Prevention and Treatment Hospital， Hangzhou 310014， China； 2.Department of General Surgery， Tongde Hospital of Zhejiang Province， Hangzhou 310012， China
[Abstract] Objective To investigate the effect of Shaofuzhuyu decoction in treating chronic pain after repair of inguinal hernia. Methods A total of 64 cases of patients with chronic pain after repair of inguinal hernia， all of which were selected from October 2008 to September 2014 in our hospital. All the patients were randomized divided into two groups. Shaofuzhuyu decoction were prescribed to the study group(n=32)， the control group(n=32) were given celecoxib. The clinical effects of the both groups on visual analogue scale(VAS) and carolinas comfort scale (CCS)， interleukin-6 (IL-6) were observed and compared. Results The total effective rate of study group was higher than control group. The difference was significant(P<0.05). The VAS in study group were less than those in control group after treatment(P<0.05)， and there was significant difference between the two groups. The CCS in study group were less than those in control group after treatment， and there was significant difference between the two groups(P<0.05). Compared with the control group， the peripheral serum IL-6 levels after treatment were significantly lower than those before treatment in study group， the difference was significant(P<0.05). Conclusion Shaofuzhuyu decoction can significantly improve the therapeutic effect in treating chronic pain post operation of inguinal hernia and also can elevate the quality of life with patients obviously.
[Key words] Shaofuzhuyu decoction； Inguinal hernia； Tension-free hernia repair； Chronic pain
成人腹股沟疝无张力修补术已广泛运用于临床，其安全性及经济性受到广泛认可，然而腹股沟疝术后慢性疼痛成了最常见最突出的后遗症。腹股沟疝修补术后慢性疼痛(chronic groin pain，CGP)是指疝修补术后持续存在时间超过3个月、范围超过手术累及区域的疼痛[1]，严重影响患者的工作和生活。由于其病因复杂，症状明显，目前该病治疗效果不理想而困扰医患双方。选择性COX-2抑制剂可以减少相关不良反应而被逐渐应用于临床镇痛治疗[2]，但停药后病情易反复。本研究以少腹逐瘀汤治疗腹股沟疝术后慢性疼痛取得了良好的效果，通过监测外周血白介素6(IL-6)以探讨其可能作用机制。现报道如下。, 百拇医药(杨颖 张喆)
[关键词] 少腹逐瘀汤；腹股沟疝；无张力疝修补术；慢性疼痛
[中图分类号] R656.2 [文献标识码] B [文章编号] 1673-9701(2015)31-0103-04
Clinical observations on Shaofuzhuyu decoction in treating 32 cases of chronic pain after repair of inguinal hernia
YANG Ying1 ZHANG Zhe2
1.Department of Occupational Disease， Hangzhou Occupational Disease Prevention and Treatment Hospital， Hangzhou 310014， China； 2.Department of General Surgery， Tongde Hospital of Zhejiang Province， Hangzhou 310012， China
[Abstract] Objective To investigate the effect of Shaofuzhuyu decoction in treating chronic pain after repair of inguinal hernia. Methods A total of 64 cases of patients with chronic pain after repair of inguinal hernia， all of which were selected from October 2008 to September 2014 in our hospital. All the patients were randomized divided into two groups. Shaofuzhuyu decoction were prescribed to the study group(n=32)， the control group(n=32) were given celecoxib. The clinical effects of the both groups on visual analogue scale(VAS) and carolinas comfort scale (CCS)， interleukin-6 (IL-6) were observed and compared. Results The total effective rate of study group was higher than control group. The difference was significant(P<0.05). The VAS in study group were less than those in control group after treatment(P<0.05)， and there was significant difference between the two groups. The CCS in study group were less than those in control group after treatment， and there was significant difference between the two groups(P<0.05). Compared with the control group， the peripheral serum IL-6 levels after treatment were significantly lower than those before treatment in study group， the difference was significant(P<0.05). Conclusion Shaofuzhuyu decoction can significantly improve the therapeutic effect in treating chronic pain post operation of inguinal hernia and also can elevate the quality of life with patients obviously.
[Key words] Shaofuzhuyu decoction； Inguinal hernia； Tension-free hernia repair； Chronic pain
成人腹股沟疝无张力修补术已广泛运用于临床，其安全性及经济性受到广泛认可，然而腹股沟疝术后慢性疼痛成了最常见最突出的后遗症。腹股沟疝修补术后慢性疼痛(chronic groin pain，CGP)是指疝修补术后持续存在时间超过3个月、范围超过手术累及区域的疼痛[1]，严重影响患者的工作和生活。由于其病因复杂，症状明显，目前该病治疗效果不理想而困扰医患双方。选择性COX-2抑制剂可以减少相关不良反应而被逐渐应用于临床镇痛治疗[2]，但停药后病情易反复。本研究以少腹逐瘀汤治疗腹股沟疝术后慢性疼痛取得了良好的效果，通过监测外周血白介素6(IL-6)以探讨其可能作用机制。现报道如下。, 百拇医药(杨颖 张喆)