[摘要] 慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)是一种常见病和多发病，给患者和社会带来巨大的经济负担。肺功能试验是诊断慢阻肺的金标准，慢阻肺急性加重的诊断则主要根据临床表现，缺乏量化指标。血清生物标记物是一种定量指标，有助于慢阻肺急性加重的诊断，可指导治疗和预测预后。本文对最新发现的血清生物标记物作一综述。

    [关键词] 慢性阻塞性肺疾病；肺功能试验；急性加重；标记物

    [中图分类号] R563.5 [文献标识码] A [文章编号] 1673-9701(2016)09-0159-04

    [Abstract] Chronic obstructive pulmonary disease(COPD) is a common and frequently-occurring disease， which may lay a huge financial burden on the patients and the society. Respiratory function tests is the gold standard for the diagnosis of COPD ......