雌激素受体、孕激素受体及原癌基因Her—2在肺腺癌中的表达(1)
[摘要] 目的 探讨雌激素受体(ER)、孕激素受体(PR)及原癌基因Her-2(C-erbB-2)在肺腺癌发生发展过程中的作用。 方法 选择2013年3月～2015年2月在我院手术治疗的肺腺癌患者组织切块60例为研究对象。分析不同性别、年龄、分化程度、临床分期患者肺腺癌中ER、PR及C-erbB-2的表达，分析肺腺癌患者组织中C-erbB-2的表达与ER、PR表达的相关性，分析骨转移患者与无骨转移患者肺腺癌组织中ER、PR、C-erbB-2的表达。 结果 60例患者，14例ER阳性表达，占23.3%，13例PR阳性，占21.7%，6例C-erbB-2阳性，占10.0%。分化程度越低的患者ER阳性率及C-erbB-2阳性率越高(P<0.05)。不同性别、临床分期肺腺癌患者组织中ER、PR及C-erbB-2表达无差异(P>0.05)。相关性分析：C-erbB-2与ER表达呈显著正相关的关系(r=0.461)，C-erbB-2表达与PR呈正相关(r=0.326)；C-erbB-2与ER及PR均为阳性呈显著正相关的关系(r=0.329)，ER与PR表达无相关性(r=0.081)。骨转移患者与无骨转移患者肺腺癌组织中ER、PR及C-erbB-2表达无差异(P>0.05)。 结论 肺腺癌中均可表达一定程度的雌激素受体、孕激素受体及原癌基因Her-2水平。
[关键词] 雌激素受体；孕激素受体；原癌基因Her-2；肺腺癌
[中图分类号] R734.2 [文献标识码] A [文章编号] 1673-9701(2016)12-0008-03
Expression of ER， PR and C-erbB-2 with lung adenocarcinoma
QIN Wenjing ZHANG Shuanglin
Department of Respiratory Medicine， the First Affiliated Hospital of He'nan University，Kaifeng 475000，China
[Abstract] Objective To discuss expression of ER，PR and C-erbB-2 with lung adenocarcinoma. Methods Diced tissues of 60 cases with lung adenocarcinoma from Mar 2013 to Feb 2015 were selected. ER， PR and C-erbB-2 levels in patients of different sex， age， degree of differentiation， clinical stage were analyzed. Association of C-erbB-2 expression with ER and PR was analyzed. ER，PR and C-erbB-2 levels in patients with bone metastases and non bone metastasis were analyzed. Results In 60 cases， ER positive expression in 14 cases， accounted for 23.3%， 13 cases of PR positive， accounted for 21.7%， and 6 cases of C-erbB-2 positive， accounted for 10%. ER and C-erbB-2 positive rates in patients with the lower the degree of differentiation were higher(P<0.05). ER， PR and C-erbB-2 positive rates in patients with different sex，there was no significant difference in the clinical stage(P>0.05). C-erbB-2 and ER expression was significantly positive correlation relationship(r=0.461)，C-erbB-2 expression and PR were positively correlated (r=0.326)； C-erbB-2，ER and PR were positive significant positive correlation relationship(r=0.329)， ER and PR expression no correlation(r=0.081). ER， PR and C-erbB-2 expressions showed no significant difference in patients with bone metastases and non bone metastasis(P>0.05). Conclusion ER，PR and C-erbB-2 express in lung adenocarcinoma.
[Key words] ER； PR； C-erbB-2； Lung adenocarcinoma
近年来内分泌治疗肿瘤取得了较大的进展，相关研究也越来越多，尤其是前列腺癌、乳腺癌等内分泌相关癌症。有学者报道肺癌组织中存在雌激素受体(estrogen receptor，ER)、孕激素受体(progesterone receptor，PR)，随后这种结论由多种方法证实[1]。肺腺癌容易发生骨转移，而骨骼中雌激素受体高表达，且两者之间可能存在一定的相关性。孕激素是雌激素的调控基因产物，反映了雌激素的功能及活性，而原癌基因Her-2(Proto-oncogene HER-2，C-erbB-2)是与雌激素受体表达相关受体，与肺癌的预后相关[2，3]。本研究分析肺腺癌患者ER、PR及C-erbB-2表达，现报道如下。, http://www.100md.com(秦文婧 张双林)
[关键词] 雌激素受体；孕激素受体；原癌基因Her-2；肺腺癌
[中图分类号] R734.2 [文献标识码] A [文章编号] 1673-9701(2016)12-0008-03
Expression of ER， PR and C-erbB-2 with lung adenocarcinoma
QIN Wenjing ZHANG Shuanglin
Department of Respiratory Medicine， the First Affiliated Hospital of He'nan University，Kaifeng 475000，China
[Abstract] Objective To discuss expression of ER，PR and C-erbB-2 with lung adenocarcinoma. Methods Diced tissues of 60 cases with lung adenocarcinoma from Mar 2013 to Feb 2015 were selected. ER， PR and C-erbB-2 levels in patients of different sex， age， degree of differentiation， clinical stage were analyzed. Association of C-erbB-2 expression with ER and PR was analyzed. ER，PR and C-erbB-2 levels in patients with bone metastases and non bone metastasis were analyzed. Results In 60 cases， ER positive expression in 14 cases， accounted for 23.3%， 13 cases of PR positive， accounted for 21.7%， and 6 cases of C-erbB-2 positive， accounted for 10%. ER and C-erbB-2 positive rates in patients with the lower the degree of differentiation were higher(P<0.05). ER， PR and C-erbB-2 positive rates in patients with different sex，there was no significant difference in the clinical stage(P>0.05). C-erbB-2 and ER expression was significantly positive correlation relationship(r=0.461)，C-erbB-2 expression and PR were positively correlated (r=0.326)； C-erbB-2，ER and PR were positive significant positive correlation relationship(r=0.329)， ER and PR expression no correlation(r=0.081). ER， PR and C-erbB-2 expressions showed no significant difference in patients with bone metastases and non bone metastasis(P>0.05). Conclusion ER，PR and C-erbB-2 express in lung adenocarcinoma.
[Key words] ER； PR； C-erbB-2； Lung adenocarcinoma
近年来内分泌治疗肿瘤取得了较大的进展，相关研究也越来越多，尤其是前列腺癌、乳腺癌等内分泌相关癌症。有学者报道肺癌组织中存在雌激素受体(estrogen receptor，ER)、孕激素受体(progesterone receptor，PR)，随后这种结论由多种方法证实[1]。肺腺癌容易发生骨转移，而骨骼中雌激素受体高表达，且两者之间可能存在一定的相关性。孕激素是雌激素的调控基因产物，反映了雌激素的功能及活性，而原癌基因Her-2(Proto-oncogene HER-2，C-erbB-2)是与雌激素受体表达相关受体，与肺癌的预后相关[2，3]。本研究分析肺腺癌患者ER、PR及C-erbB-2表达，现报道如下。, http://www.100md.com(秦文婧 张双林)