[摘要] 目的 探讨帕罗西汀联合奥氮平治疗抑郁症的临床疗效。 方法 随机选取我院收治的抑郁症患者100例，随机分成观察组50例，对照组50例。对照组患者给予盐酸帕罗西汀片口服治疗，观察组患者在对照组的基础上给予奥氮平片口服治疗，6个月后比较两组患者的总有效率，采用汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)及副反应量表(TESS)对两组患者的治疗第1、3、6个月的抑郁、睡眠程度及不良反应情况进行观察评价。 结果 6个月后观察组患者的总有效率明显高于对照组；经1、3、6个月治疗后，观察组患者的HAMD及PSQI明显降低，TESS无明显差异。 结论 帕罗西汀联合奥氮平治疗抑郁症可明显减轻患者抑郁，缓解睡眠，副反应少，值得临床推广。

    [关键词] 帕罗西汀；奥氮平；抑郁症；汉密尔顿抑郁量表；匹兹堡睡眠质量指数；副反应量表

    [中图分类号] R749.4 [文献标识码] B [文章编号] 1673-9701(2016)14-0106-03

    [Abstract] Objective To explore the clinical curative effects of paroxetine combined with olanzapine in the treatment of depression. Methods 100 patients with depression who were admitted to our hospital were randomly selected. They were randomly assigned to the observation group with 50 patients and the control group with 50 patients. The control group was orally given paroxetine hydrochloride ......