[摘要] 目的 探讨化疗与生物免疫疗法治疗胃癌的疗效及对循环肿瘤细胞(CTC)的影响。 方法 将80例胃癌患者分为对照组与观察组，对照组仅采用化疗，观察组联合DC-CIK生物免疫疗法进行治疗。比较两组的疗效及两组治疗前后的CTC水平。 结果 (1)观察组治疗后的临床总缓解率显著高于对照组(P<0.05)；(2)观察组治疗后的CTC检出率均显著低于治疗前及对照组(P<0.05)。 结论 化疗联合生物免疫治疗胃癌临床疗效显著，可有效降低CTC水平，值得临床推广和应用。

    [关键词] 胃癌；化疗；DC-CIK细胞；循环肿瘤细胞

    [中图分类号] R735 [文献标识码] A [文章编号] 1673-9701(2017)12-0025-03

    [Abstract] Objective To investigate the effect of chemotherapy and bioimmune therapy on gastric cancer and its effect on circulating tumor cells(CTC). Methods Eighty patients with gastric cancer diagnosed by postoperative pathology were divided into control group and observation group. The control group was treated with chemotherapy only. The observation group was treated with DC-CIK biological immunotherapy. The effect and the CTC levels of two groups before and after treatment were compared. Results (1)The total clinical remission rate in the observation group was significantly higher than that in the control group(P<0.05)； (2)The detection rate of CTC in the observation group was significantly lower than that before treatment and the control group(P<0.05). Conclusion The clinical effect of chemotherapy combined with biological immunotherapy for gastric cancer is significant ......