老年肥胖患者血浆视黄醇结合蛋白4水平与血压及胰岛素抵抗相关性研究(1)
[摘要] 目的 測定老年肥胖患者及正常者血浆视黄醇结合蛋白4水平，分析其与收缩压、舒张压、胰岛素抵抗、血糖、胰岛素、血脂、腰臀比、腰围、年龄的相关性。 方法 以老年肥胖患者43例为病例组，老年健康人群41 例为对照组。测量血压、腰围、身高、臀围、体重。抽取空腹静脉血，测定血浆视黄醇结合蛋白4、胰岛素、血糖、血脂(甘油三酯、高密度脂蛋白胆固醇、总胆固醇、低密度脂蛋白胆固醇)水平，计算体重指数、腰臀比、胰岛素抵抗指数、体内脂肪百分比。 结果 老年肥胖患者血浆视黄醇结合蛋白4水平显著高于对照组(P<0.01)；老年肥胖组患者血浆视黄醇结合蛋白4水平与年龄、收缩压、舒张压、体重指数、胰岛素、胰岛素抵抗指数、HDL-C呈正相关；对照组血浆视黄醇结合蛋白4水平与臀围、空腹血糖呈正相关，与其他指标无相关性。 结论 老年肥胖组患者血浆视黄醇结合蛋白4水平升高并与年龄、收缩压、舒张压、体重指数、胰岛素、胰岛素抵抗指数、HDL-C之间存在一定的相关性。
[关键词] 肥胖；视黄醇结合蛋白4；胰岛素抵抗；血压
[中图分类号] R589.2 [文献标识码] A [文章编号] 1673-9701(2017)21-0001-03
Study on the relationship between the level of plasma retinol binding protein 4 and blood pressure and insulin resistance in elderly obese patients
JIA Dongxia1 PENG Junchen2 LIU Sitai1 HOU Liangping1 ZHENG Hang1 LI Lan1 DU Yan1
1.Department of Geriatrics， Mianyang No.404 Hospital in Sichuan Province， Mianyang 621000， China； 2.Department of Gynecology and Obstetrics， Mianyang No.404 Hospital in Sichuan Province， Mianyang 621000， China
[Abstract] Objective To determine the level of plasma retinol binding protein 4 in elderly obese patients and normal subjects， and analyze its relationship with systolic blood pressure， diastolic blood pressure， insulin resistance， blood glucose， insulin， blood lipid， waist to hip ratio， waist circumference and age. Methods The 43 obese elderly patients were selected as the case group， and 41 healthy elderly subjects were selected as the control group. The blood pressure， waist circumference， height， hip circumference， and body weight were measured. The fasting venous blood was collected. The levels of plasma retinol binding protein 4， insulin， blood glucose， blood lipid (triglyceride， high density lipoprotein cholesterol， total cholesterol， low density lipoprotein cholesterol) were determined， and body mass index， waist to hip ratio， insulin resistance index， and body fat percentage were calculated. Results The levels of plasma retinol binding protein 4 in elderly obese patients were significantly higher than those in control group (P<0.01)； The levels of plasma retinol binding protein 4 in elderly obese patients were positively correlated with age， systolic blood pressure， diastolic blood pressure， body mass index， insulin， insulin resistance index and HDL-C； there were positive correlations between plasma retinol binding protein 4 level and hip circumference and fasting blood glucose in the control group， but no correlation with other indices. Conclusion The levels of plasma retinol binding protein 4 in elderly obese patients are correlated with age， systolic blood pressure， diastolic blood pressure， body mass index， insulin， insulin resistance index and HDL-C., 百拇医药(贾冬霞 彭君臣 刘思泰 侯良平 郑航 李兰 杜燕)
[关键词] 肥胖；视黄醇结合蛋白4；胰岛素抵抗；血压
[中图分类号] R589.2 [文献标识码] A [文章编号] 1673-9701(2017)21-0001-03
Study on the relationship between the level of plasma retinol binding protein 4 and blood pressure and insulin resistance in elderly obese patients
JIA Dongxia1 PENG Junchen2 LIU Sitai1 HOU Liangping1 ZHENG Hang1 LI Lan1 DU Yan1
1.Department of Geriatrics， Mianyang No.404 Hospital in Sichuan Province， Mianyang 621000， China； 2.Department of Gynecology and Obstetrics， Mianyang No.404 Hospital in Sichuan Province， Mianyang 621000， China
[Abstract] Objective To determine the level of plasma retinol binding protein 4 in elderly obese patients and normal subjects， and analyze its relationship with systolic blood pressure， diastolic blood pressure， insulin resistance， blood glucose， insulin， blood lipid， waist to hip ratio， waist circumference and age. Methods The 43 obese elderly patients were selected as the case group， and 41 healthy elderly subjects were selected as the control group. The blood pressure， waist circumference， height， hip circumference， and body weight were measured. The fasting venous blood was collected. The levels of plasma retinol binding protein 4， insulin， blood glucose， blood lipid (triglyceride， high density lipoprotein cholesterol， total cholesterol， low density lipoprotein cholesterol) were determined， and body mass index， waist to hip ratio， insulin resistance index， and body fat percentage were calculated. Results The levels of plasma retinol binding protein 4 in elderly obese patients were significantly higher than those in control group (P<0.01)； The levels of plasma retinol binding protein 4 in elderly obese patients were positively correlated with age， systolic blood pressure， diastolic blood pressure， body mass index， insulin， insulin resistance index and HDL-C； there were positive correlations between plasma retinol binding protein 4 level and hip circumference and fasting blood glucose in the control group， but no correlation with other indices. Conclusion The levels of plasma retinol binding protein 4 in elderly obese patients are correlated with age， systolic blood pressure， diastolic blood pressure， body mass index， insulin， insulin resistance index and HDL-C., 百拇医药(贾冬霞 彭君臣 刘思泰 侯良平 郑航 李兰 杜燕)