前列地尔治疗糖尿病合并慢性肾脏疾病患者的临床研究(1)
[摘要] 目的 探讨在常规治疗的基础上联合前列地尔治疗老年糖尿病合并肾脏疾病的临床疗效和安全性。 方法 选择2015年5月～2016年5月我院收治并明确诊断为糖尿病合并肾脏疾病的88例老年患者为研究对象，采取投掷硬币的方法将其随机平均分为两组。对照组予以调整血糖、血脂、血压等口服药物常规治疗，实验组在此基础上予以前列地尔口服治疗，对比观察两组患者临床疗效及不良反应情况。 结果 实验组患者总有效率为95.45%，明显高于对照组的70.45%(P<0.05)；治疗前两组患者肾功能各指标差异无统计学意义(P>0.05)，两组患者经治疗后各指标均明显好转(P<0.05)，治疗后对照组各指标与实验组相比，差异均有统计学意义(P<0.05)；实验组患者不良反应总发生率为29.55%，略高于对照组不良反应总发生率(20.45%)，但差异无统计学意义(P>0.05)。 结论 前列地尔治疗老年糖尿病合并慢性肾脏疾病患者临床疗效好，安全性好，值得临床广泛推广。
[关键词] 糖尿病；慢性肾脏病；前列地尔；安全性
[中图分类号] R587.2；R692.9 [文献标识码] B [文章编号] 1673-9701(2018)06-0035-03
[Abstract] Objective To study the clinical curative effect and safety of combined alprostadil in the treatment of geriatric diabetes mellitus complicated with kidney disease on the basis of routine treatment. Methods From May 2015 to May 2016， 88 elderly patients who were admitted to our hospital and diagnosed as diabetes complicated with kidney disease were selected as the study subjects. The method of flipping coins was used to randomly divide the patients into two groups. The control group was orally given conventional treatment of drugs used to adjust blood sugar， blood lipids， blood pressure and others. The experimental group was orally given alprostadil on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared and observed. Results The total effective rate in the experimental group was 95.45%， which was significantly higher than that of 70.45% in the control group(P<0.05)； there was no statistically significant difference in each index of renal function between the two groups before treatment(P>0.05). After treatment， the two groups of patients were significantly improved in all indexes(P<0.05). After treatment， the indexes in the control group were statistically significantly different from those in the experimental group(P<0.05)； the total incidence rate of adverse reactions in the experimental group was 29.55%， slightly higher than that of 20.45% in the control group， and the difference was not statistically significant(P>0.05). Conclusion Alprostadil in the treatment of geriatric diabetes mellitus complicated with chronic kidney disease has a good clinical curative effect and good safety， which is worthy of widespread clinical application.
[Key words] Diabetes； Chronic kidney disease； Alprostadil； Safety
糖尿病合并慢性腎脏疾病在临床上多发，尤其是在中老年人群[1]。随着我国老年人口的不断增加，其有效的治疗方法愈发受到临床工作者的重视。糖尿病发病机制很复杂，其对患者全身系统的损害十分严重[2-3]，如何改善糖尿病合并慢性肾脏疾病患者肾脏功能的损害，对于提高患者生活质量，降低患者的死亡率具有十分重要的意义[4-5]。前列腺素E1类的药物是目前治疗糖尿病合并慢性肾脏疾病患者的研究热点并且在临床上已广泛使用，国内已有相关研究表明前列地尔治疗糖尿病合并慢性肾脏疾病治疗有效[6-7]，但是均为小样本，集中在某一地区的报道，未见本地区相关报道。为研究其疗效，选择2015年5月～2016年5月我院收治并明确诊断为糖尿病合并肾脏疾病的98例老年患者进行实验研究，现报道如下。, http://www.100md.com(杨燕丽 臧淑妃 张秋玲)
[关键词] 糖尿病；慢性肾脏病；前列地尔；安全性
[中图分类号] R587.2；R692.9 [文献标识码] B [文章编号] 1673-9701(2018)06-0035-03
[Abstract] Objective To study the clinical curative effect and safety of combined alprostadil in the treatment of geriatric diabetes mellitus complicated with kidney disease on the basis of routine treatment. Methods From May 2015 to May 2016， 88 elderly patients who were admitted to our hospital and diagnosed as diabetes complicated with kidney disease were selected as the study subjects. The method of flipping coins was used to randomly divide the patients into two groups. The control group was orally given conventional treatment of drugs used to adjust blood sugar， blood lipids， blood pressure and others. The experimental group was orally given alprostadil on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared and observed. Results The total effective rate in the experimental group was 95.45%， which was significantly higher than that of 70.45% in the control group(P<0.05)； there was no statistically significant difference in each index of renal function between the two groups before treatment(P>0.05). After treatment， the two groups of patients were significantly improved in all indexes(P<0.05). After treatment， the indexes in the control group were statistically significantly different from those in the experimental group(P<0.05)； the total incidence rate of adverse reactions in the experimental group was 29.55%， slightly higher than that of 20.45% in the control group， and the difference was not statistically significant(P>0.05). Conclusion Alprostadil in the treatment of geriatric diabetes mellitus complicated with chronic kidney disease has a good clinical curative effect and good safety， which is worthy of widespread clinical application.
[Key words] Diabetes； Chronic kidney disease； Alprostadil； Safety
糖尿病合并慢性腎脏疾病在临床上多发，尤其是在中老年人群[1]。随着我国老年人口的不断增加，其有效的治疗方法愈发受到临床工作者的重视。糖尿病发病机制很复杂，其对患者全身系统的损害十分严重[2-3]，如何改善糖尿病合并慢性肾脏疾病患者肾脏功能的损害，对于提高患者生活质量，降低患者的死亡率具有十分重要的意义[4-5]。前列腺素E1类的药物是目前治疗糖尿病合并慢性肾脏疾病患者的研究热点并且在临床上已广泛使用，国内已有相关研究表明前列地尔治疗糖尿病合并慢性肾脏疾病治疗有效[6-7]，但是均为小样本，集中在某一地区的报道，未见本地区相关报道。为研究其疗效，选择2015年5月～2016年5月我院收治并明确诊断为糖尿病合并肾脏疾病的98例老年患者进行实验研究，现报道如下。, http://www.100md.com(杨燕丽 臧淑妃 张秋玲)