[摘要] 目的 探讨阿替普酶对急性缺血性小卒中的临床疗效。 方法 选取浙江省海盐县人民医院2016年1月～2017年2月使用阿替普酶的急性缺血性小卒中患者共28例为观察组，随机选取28例急性缺血性小卒中患者予抗血小板聚集等常规治疗为对照组。观察阿替普酶对急性缺血性小卒中患者神经功能的影响，同时对观察组与对照组两组治疗方式进行临床疗效和安全性评估。 结果 缺血性小卒中患者溶栓治疗前后NIHSS评分差异有统计学意义(P<0.05)，两组患者住院7 d时NIHSS评分无明显差异(P>0.05)，两组出血事件发生率无统计学差异(P>0.05)。 结论 阿替普酶可快速改善急性缺血性小卒中患者的神经功能缺损症状，且相对抗血小板聚集治疗患者未增加其出血风险。但两种治疗方式对患者住院7 d时神经功能缺损的改善无差别。

    [关键词] 阿替普酶；缺血性小卒中；NIHSS评分；出血事件发生率

    [中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701(2018)07-0104-04

    [Abstract] Objective To investigate the clinical effect of alteplase on acute ischemic stroke. Methods A total of 28 acute ischemic stroke patients treated with alteplase from January 2016 to February 2017 in Jiaxing Haiyan People's Hospital were selected as the observation group and 28 patients with acute ischemic stroke who were treated with routine treatment such as anti-platelet aggregation were selected as the control group. The effect of alteplase on the neurological function in patients with acute ischemic stroke was observed. In addition ......