多发性骨髓瘤继发骨髓纤维化的骨髓病理学特征及与疾病预后的关系评价(1)
[摘要] 目的 探讨多发性骨髓瘤患者继发骨髓纤维化的骨髓病理学特征以及继发骨髓纤维化同疾病预后之间的相关性。 方法 选择2016年1～12月期间本院接收的80例多发性骨髓瘤患者的临床资料，分析40例未继发骨髓纤维化患者及40例继发骨髓纤维化的骨髓病理学特征，对骨髓涂片及活检增生程度、疾病分期及疾病分型、生存率进行比较。 结果 骨髓活检相较于骨髓涂片而言，对多发性骨髓瘤继发骨髓纤维化患者骨髓增生程度的判断准确率更高(P<0.05);患者的骨髓纤维组织有不同程度的增生存在，在疾病好转后部分患者的骨髓纤维化程度减轻;多发性骨髓瘤继发骨髓纤维化患者以及未继发骨髓纤维化患者之间对比疾病分期、疾病类型差异无统计学意义(P>0.05);多发性骨髓瘤继发骨髓纤维化患者的两年生存率低于未继发骨髓纤维化患者(P<0.05)。结论 多发性骨髓瘤继发骨髓纤维化患者采用骨髓活检进行诊断具有较高的价值，且继发骨髓纤维化患者的预后效果不如未继发骨髓纤维化患者。
[关键词] 多发性骨髓瘤;继发骨髓纤维化;病理学特征;预后
[中圖分类号] R553.1 [文献标识码] A [文章编号] 1673-9701(2019)19-0010-03
[Abstract] Objective To investigate the pathological features of bone marrow fibrosis secondary to multiple myeloma and the correlation between secondary myelofibrosis and disease prognosis. Methods The clinical data of 80 patients with multiple myeloma received from January 2016 to December 2016 were analyzed. The pathological features of bone marrow in 40 patients with no secondary fibrosis and 40 patients with secondary myelofibrosis were analyzed. The bone marrow smear and biopsy hyperplasia， disease stage， disease classification and survival rate were compared. Results Compared with that of bone marrow smear， the accuracy of bone marrow biopsy in multiple myeloma patients with secondary myelofibrosis was higher(P<0.05). The bone marrow fibrous tissue of patients had different degrees of hyperplasia. In some patients， the degree of myelofibrosis was reduced after the disease improved. There was no significant difference in the disease stage and disease type between patients with multiple myeloma secondary myelofibrosis and those without secondary myelofibrosis(P>0.05). The two-year survival rate of patients with multiple myeloma secondary myelofibrosis was lower than that of patients without secondary myelofibrosis(P<0.05). Conclusion Bone marrow biopsy has high value in the diagnosis of multiple myeloma patients with secondary myelofibrosis， and the prognosis of patients with secondary myelofibrosis is not as good as that of patients without secondary fibrosis.
[Key words] Multiple myeloma; Secondary myelofibrosis; Pathological features; Prognosis
多发性骨髓瘤是一种恶性浆细胞病[1]，在40岁以上的群体中多发，以出血、感染、神经症状、贫血、骨痛等为主要临床症状[2]，同时还伴有肾功能损害、肝脾肿大等情况。骨髓检查是常用于诊断多发性骨髓瘤的重要手段，本文旨在分析该病患者继发骨髓纤维化的骨髓病理学特征，并探究其同预后的相关性，以促进该病患者预后的改善，选取80例多发性骨髓瘤患者作为观察对象进行分析，现报道如下。
1 资料与方法
1.1 一般资料
选取2016年1～12月多发性骨髓瘤患者80例开展本次研究。依据是否继发骨髓纤维化分为未继发骨髓纤维化组与继发骨髓纤维化组，各40例。其中未继发骨髓纤维化组中男25例，女15例，年龄24～77岁，平均值(57.99±6.54)岁;继发骨髓纤维化组中男24例，女16例，年龄24～78岁，平均(58.04±6.61)岁。两组的一般资料进行比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(张彦 李丽 高丹 李化敏)
[关键词] 多发性骨髓瘤;继发骨髓纤维化;病理学特征;预后
[中圖分类号] R553.1 [文献标识码] A [文章编号] 1673-9701(2019)19-0010-03
[Abstract] Objective To investigate the pathological features of bone marrow fibrosis secondary to multiple myeloma and the correlation between secondary myelofibrosis and disease prognosis. Methods The clinical data of 80 patients with multiple myeloma received from January 2016 to December 2016 were analyzed. The pathological features of bone marrow in 40 patients with no secondary fibrosis and 40 patients with secondary myelofibrosis were analyzed. The bone marrow smear and biopsy hyperplasia， disease stage， disease classification and survival rate were compared. Results Compared with that of bone marrow smear， the accuracy of bone marrow biopsy in multiple myeloma patients with secondary myelofibrosis was higher(P<0.05). The bone marrow fibrous tissue of patients had different degrees of hyperplasia. In some patients， the degree of myelofibrosis was reduced after the disease improved. There was no significant difference in the disease stage and disease type between patients with multiple myeloma secondary myelofibrosis and those without secondary myelofibrosis(P>0.05). The two-year survival rate of patients with multiple myeloma secondary myelofibrosis was lower than that of patients without secondary myelofibrosis(P<0.05). Conclusion Bone marrow biopsy has high value in the diagnosis of multiple myeloma patients with secondary myelofibrosis， and the prognosis of patients with secondary myelofibrosis is not as good as that of patients without secondary fibrosis.
[Key words] Multiple myeloma; Secondary myelofibrosis; Pathological features; Prognosis
多发性骨髓瘤是一种恶性浆细胞病[1]，在40岁以上的群体中多发，以出血、感染、神经症状、贫血、骨痛等为主要临床症状[2]，同时还伴有肾功能损害、肝脾肿大等情况。骨髓检查是常用于诊断多发性骨髓瘤的重要手段，本文旨在分析该病患者继发骨髓纤维化的骨髓病理学特征，并探究其同预后的相关性，以促进该病患者预后的改善，选取80例多发性骨髓瘤患者作为观察对象进行分析，现报道如下。
1 资料与方法
1.1 一般资料
选取2016年1～12月多发性骨髓瘤患者80例开展本次研究。依据是否继发骨髓纤维化分为未继发骨髓纤维化组与继发骨髓纤维化组，各40例。其中未继发骨髓纤维化组中男25例，女15例，年龄24～77岁，平均值(57.99±6.54)岁;继发骨髓纤维化组中男24例，女16例，年龄24～78岁，平均(58.04±6.61)岁。两组的一般资料进行比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(张彦 李丽 高丹 李化敏)