血液透析对慢性肾脏病合并颈动脉粥样硬化的疗效、肾功能及微炎症状态的影响(1)
[摘要] 目的 探討血液透析对慢性肾脏病合并颈动脉粥样硬化的疗效、肾功能及微炎症状态的影响。 方法 选取2017年1月～2018年1月在我院住院治疗的慢性肾脏病合并颈动脉粥样硬化患者100例作为观察对象，应用随机数字表法分为观察组和对照组，每组各50例。对照组采取保守治疗，观察组联合血液透析治疗，观察两组患者治疗后的临床疗效、肾功能指标的变化情况及两组患者治疗前后CRP、IL-6 水平的变化情况。 结果 观察组患者治疗后的总有效率达98.0%，对照组达70.0%，两组患者总有效率比较，差异具有显著性(P<0.05)。治疗前，两组患者的肾功能指标SCr、BUN及Ccr 水平比较，差异无显著性(P>0.05);治疗后，观察组患者的肾功能指标SCr、BUN 水平较治疗前显著降低，Ccr 水平较治疗前明显提高，差异具有显著性(P<0.05)，且观察组患者的肾功能指标SCr、BUN 水平明显低于对照组，Ccr 水平明显高于对照组，差异具有显著性(P<0.05)。治疗前，两组患者的CRP、IL-6 水平比较，差异无显著性(P>0.05);治疗后，观察组患者的CRP、IL-6 水平较治疗前显著降低，差异具有显著性(P<0.05)。且治疗后，观察组患者的CRP、IL-6 水平明显低于对照组，差异具有显著性(P<0.05)。 结论 对慢性肾脏病合并颈动脉粥样硬化患者应用血液透析治疗能显著提高临床疗效，改善肾功能，抑制炎症反应。
[关键词] 血液透析;慢性肾脏病;颈动脉粥样硬化;肾功能;微炎症状态
[中图分类号] R692 [文献标识码] A [文章编号] 1673-9701(2019)20-0011-04
Effect of hemodialysis on the efficacy， renal function and microinflammation of patients with chronic kidney disease complicated with carotid atherosclerosis
FENG Weiwei BAO Beiyan CHEN Qijun SHI Ling FAN Wangyang ZHAO Jun
Department of Nephrology， the Second Hospital in Yinzhou District of Ningbo City， Ningbo 315040，China
[Abstract] Objective To discuss the effect of hemodialysis on the efficacy， renal function and microinflammation of patients with chronic kidney disease complicated with carotid atherosclerosis. Methods 100 patients with chronic kidney disease and carotid atherosclerosis who were hospitalized in our hospital from January 2017 to January 2018 were selected as subjects. The patients were randomly divided into observation group and control group， 50 cases in each group. The control group was given conservative treatment. The observation group was combined with hemodialysis. The clinical efficacy， renal function index and the changes of CRP and IL-6 levels before and after treatment in the two groups were observed and compared. Results The total effective rate of the observation group was 98.0%， and the total effective rate of the control group was 70.0%. The difference was significant(P<0.05). Before treatment， the levels of SCr， BUN and Ccr in the observation group and the control group were not significantly different(P>0.05). After treatment， the levels of SCr and BUN in the observation group were significantly lower than those before treatment， and the level of Ccr was significantly higher than that before treatment(P<0.05). The levels of SCr and BUN in the observation group were significantly lower than those in the control group， and the Ccr level was significantly higher than that in the control group(P<0.05). Before treatment， the CRP and IL-6 levels in the observation group and the control group were not significantly different(P>0.05). After treatment， the levels of CRP and IL-6 in the observation group were significantly lower than those before treatment， and the Ccr level was significantly higher than that before treatment， and the difference was significant(P<0.05). After treatment， the levels of CRP and IL-6 in the observation group were significantly lower than those in the control group(P<0.05). Conclusion For patients with chronic kidney disease and carotid atherosclerosis， hemodialysis can significantly improve clinical efficacy， improve renal function， and inhibit inflammatory response., http://www.100md.com(冯微微 包蓓艳 陈其军 施翎 范汪洋 赵君)
[关键词] 血液透析;慢性肾脏病;颈动脉粥样硬化;肾功能;微炎症状态
[中图分类号] R692 [文献标识码] A [文章编号] 1673-9701(2019)20-0011-04
Effect of hemodialysis on the efficacy， renal function and microinflammation of patients with chronic kidney disease complicated with carotid atherosclerosis
FENG Weiwei BAO Beiyan CHEN Qijun SHI Ling FAN Wangyang ZHAO Jun
Department of Nephrology， the Second Hospital in Yinzhou District of Ningbo City， Ningbo 315040，China
[Abstract] Objective To discuss the effect of hemodialysis on the efficacy， renal function and microinflammation of patients with chronic kidney disease complicated with carotid atherosclerosis. Methods 100 patients with chronic kidney disease and carotid atherosclerosis who were hospitalized in our hospital from January 2017 to January 2018 were selected as subjects. The patients were randomly divided into observation group and control group， 50 cases in each group. The control group was given conservative treatment. The observation group was combined with hemodialysis. The clinical efficacy， renal function index and the changes of CRP and IL-6 levels before and after treatment in the two groups were observed and compared. Results The total effective rate of the observation group was 98.0%， and the total effective rate of the control group was 70.0%. The difference was significant(P<0.05). Before treatment， the levels of SCr， BUN and Ccr in the observation group and the control group were not significantly different(P>0.05). After treatment， the levels of SCr and BUN in the observation group were significantly lower than those before treatment， and the level of Ccr was significantly higher than that before treatment(P<0.05). The levels of SCr and BUN in the observation group were significantly lower than those in the control group， and the Ccr level was significantly higher than that in the control group(P<0.05). Before treatment， the CRP and IL-6 levels in the observation group and the control group were not significantly different(P>0.05). After treatment， the levels of CRP and IL-6 in the observation group were significantly lower than those before treatment， and the Ccr level was significantly higher than that before treatment， and the difference was significant(P<0.05). After treatment， the levels of CRP and IL-6 in the observation group were significantly lower than those in the control group(P<0.05). Conclusion For patients with chronic kidney disease and carotid atherosclerosis， hemodialysis can significantly improve clinical efficacy， improve renal function， and inhibit inflammatory response., http://www.100md.com(冯微微 包蓓艳 陈其军 施翎 范汪洋 赵君)