α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变的临床效果观察(1)
[摘要] 目的 探討α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变的临床效果。 方法 选择2017年3月～2019年2月本院收治的82例糖尿病周围神经病变患者，按随机数字表法分为对照组和观察组，每组41例。两组均给予控制血糖和控制血脂的常规治疗，对照组在此基础上服用甲钴胺，观察组在上述基础上加用α-硫辛酸，对比两组疗效、氧化应激指标和胫前及腓总神经传导功能。 结果 治疗后，观察组治疗总有效率为95.13%，高于对照组的78.05%，差异有统计学意义(P<0.05);治疗后，观察组SOD水平[(32.24±4.14)nmol/mL]高于对照组[(30.21±4.29)nmol/mL]，MDA水平[(3.56±0.67)U/mL]低于对照组[(4.82±0.85)U/mL]，差异有统计学意义(P<0.05);治疗后，观察组胫前神经和腓总神经的MCV、SCV均高于对照组，差异有统计学意义(P<0.05)。 结论 糖尿病周围神经病变患者采用α-硫辛酸联合甲钴胺治疗，有利于改善患者病情，抑制氧化应激反应对神经的损害，提高神经传导速度，且疗效高于甲钴胺单一用药。
[关键词] 糖尿病周围神经病变;α-硫辛酸;甲钴胺;氧化应激指标;神经传导功能
[中图分类号] R587.2 [文献标识码] B [文章编号] 1673-9701(2019)27-0047-03
[Abstract] Objective To investigate the clinical effect of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy. Methods A total of 82 patients with diabetic peripheral neuropathy who were admitted to our hospital from March 2017 to February 2019 were selected. According to the random number table method， they were divided into the control group and the observation group， with 41 cases in each group. Both groups were given conventional treatment for controlling blood sugar and controlling blood lipids. The control group was given mecobalamin on this basis. The observation group was further given α-lipoic acid on the above basis. The efficacy， oxidative stress indices， and the conduction function of anterior tibial nerve and common peroneal nerve were compared between two groups. Results After treatment， the total effective rate in the observation group was 95.13%， which was higher than that of 78.05% in the control group， and the difference was statistically significant(P<0.05); after treatment， the SOD level was (32.24±4.14) nmol/mL in the observation group， which was higher than that of (30.21±4.29) nmol/mL in the control group. The MDA level was (3.56±0.67) U/mL， which was lower than that of (4.82±0.85) U/mL in the control group， and the difference was statistically significant(P<0.05); after treatment， the MCV and SCV of the anterior tibial nerve and the common peroneal nerve in the observation group were higher than those in the control group， and the differences were statistically significant (P<0.05). Conclusion Patients with diabetic peripheral neuropathy treated with α-lipoic acid combined with mecobalamin are beneficial to improving the patients' condition， inhibiting the damage of nerves caused by oxidative stress response， and increasing the nerve conduction velocity， and the curative effect is higher than that of mecobalamin alone., 百拇医药(李添翼)
[关键词] 糖尿病周围神经病变;α-硫辛酸;甲钴胺;氧化应激指标;神经传导功能
[中图分类号] R587.2 [文献标识码] B [文章编号] 1673-9701(2019)27-0047-03
[Abstract] Objective To investigate the clinical effect of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy. Methods A total of 82 patients with diabetic peripheral neuropathy who were admitted to our hospital from March 2017 to February 2019 were selected. According to the random number table method， they were divided into the control group and the observation group， with 41 cases in each group. Both groups were given conventional treatment for controlling blood sugar and controlling blood lipids. The control group was given mecobalamin on this basis. The observation group was further given α-lipoic acid on the above basis. The efficacy， oxidative stress indices， and the conduction function of anterior tibial nerve and common peroneal nerve were compared between two groups. Results After treatment， the total effective rate in the observation group was 95.13%， which was higher than that of 78.05% in the control group， and the difference was statistically significant(P<0.05); after treatment， the SOD level was (32.24±4.14) nmol/mL in the observation group， which was higher than that of (30.21±4.29) nmol/mL in the control group. The MDA level was (3.56±0.67) U/mL， which was lower than that of (4.82±0.85) U/mL in the control group， and the difference was statistically significant(P<0.05); after treatment， the MCV and SCV of the anterior tibial nerve and the common peroneal nerve in the observation group were higher than those in the control group， and the differences were statistically significant (P<0.05). Conclusion Patients with diabetic peripheral neuropathy treated with α-lipoic acid combined with mecobalamin are beneficial to improving the patients' condition， inhibiting the damage of nerves caused by oxidative stress response， and increasing the nerve conduction velocity， and the curative effect is higher than that of mecobalamin alone., 百拇医药(李添翼)