段秀萍 何赟 梁靖梅 李福记 廖蕴华

    [关键词] 苦参碱;成纤维细胞生长因子2;人腹膜间皮细胞;上皮间充质转分化;TGF-β1

    [中图分类号] R563? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)18-0015-04

    Regulation effect of matrine on fibroblast growth factor 2 induced by TGF-β1 in human peritoneal mesothelial cells

    DUAN Xiuping? ?HE Yun? ?LIANG Jingmei? ?LI Fuji? ?LIAO Yunhua

    Department of Nephrology， the First Affiliated Hospital of Guangxi Medical University， Nanning? ?530021， China

    [Abstract] Objective To investigate the regulatory effect of matrine on fibroblast growth factor 2 (FGF-2) during epithelial mesenchymal transition (EMT) of peritoneal mesenchymal cells. Methods Human peritoneal mesothelial cells were divided into three groups according to different treatment methods (the control group， the TGF-β1 stimulation group and the TGF-β1+0.8 mg/mL matrine treatment group). The complete medium containing 5 ng/mL TGF-β1 was used in the TGF-β1 stimulation group ......