唐艺玲 张培蓓 叶贤伟

    [关键词] PI3K-Akt-mTOR;慢性阻塞性肺疾病(慢阻肺);自噬;基因治疗

    [中图分类号] R856.3? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)18-0178-06

    Research progress of PI3K-Akt-mTOR pathway in the pathogenesis of chronic obstructive pulmonary disease

    TANG Yiling1? ?ZHANG Peibei2，3? ?YE Xianwei1， 3

    1.Zunyi Medical University，Zunyi 563000，China;2.Department of Respiratory and Critical Care Medicine，Guizhou Provincial People's Hospital， Guiyang 550000， China; 3.Key Laboratory of Pulmonary Immune Diseases， National Health Commission， Guiyang? ?550000， China

    [Abstract] Chronic obstructive pulmonary disease (abbreviated as COPD)， which is an inflammatory disease of the airway in the respiratory mechanism of the human body， has a certain commonness， and its morbidity and fatality rate are both high. It is an important global public health issue. Through related investigations， it is found that the phosphatidylinositol 3-kinase/protein kinase B/target of rapamycin (P13K-Akt-mTOR) signaling pathway is involved in many aspects of the cell， such as proliferation， apoptosis， and autophagy ......