周文灿 钟胜芬

    [關键词] 抗生素;感染性肺炎;肠道菌群;D-乳酸

    [中图分类号] R563.1? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2021)27-0049-05

    Effect of single and combined use of different dosage forms of antibiotics in children with pneumonia and their influence on intestinal microecology

    ZHOU Wencan1? ?ZHONG Shengfen2

    1.Zhejiang University of Traditional Chinese Medicine， Hangzhou? ?310053， China; 2.Department of Pharmacy， Fuyang District Maternity and Child Health Hospital， Hangzhou? ?311400， China

    [Abstract] Objective To investigate the effect of single and combined use of different dosage forms of antibiotics in children with infectious pneumonia and their influence on intestinal microecology. Methods A total of 96 neonates with infectious pneumonia treated in our hospital from August 2019 to August 2020 were selected and divided into the penicillin group， the cephalosporin group， and the combination group using random drawing method， with 32 patients in each group. The penicillin group were treated with penicillin， the cephalosporin group were treated with ceftizoxime， and the combination group were treated with penicillin combined with ceftizoxime. All three groups were treated for 1 week. Fluorescence quantitative PCR was used to detect the number of intestinal flora in feces. Enzyme-linked immunosorbent assay was used to detect the levels of tumor necrosis factor-α (TNF-α) ......