王宇威 刘近春 安秀琴 柴茹

    [摘要] 非酒精性脂肪性肝病(NAFLD)已成为当前世界范围内最主要的慢性肝病之一，目前除了改变生活方式外，尚未确定确切的治疗方法。随着肠-肝轴理论的提出，本研究逐渐认识到肠道菌群及其代谢产物与宿主的代谢状况密切相关，除了肠道菌群本身，基于肠道菌群分泌、修饰和降解的代谢物也是宿主-菌群对话的重要媒介，同时也参与宿主代谢的调节，肠道菌群和相关代谢的失调可以被认为是NAFLD病理生理学的调节者，这也为“肠道菌群失调可引起肝脏病理生理改变”提供理论基础。因此，调节肠道微生态成为治疗NAFLD的一大热点，目前多个研究已经提出调节肠道菌群的治疗方法，包括益生菌、益生元、合生元的应用。本文就肠道菌群如何参与NAFLD发病过程及针对肠道菌群靶向治疗NAFLD做一综述。

    [关键词] 非酒精性脂肪性肝病;肠-肝轴;肠道微生态;微生物制剂

    [中图分类号] R575.1? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2022)15-0192-05

    Research progress of intestinal microecology and non-alcoholic fatty liver disease

    WANG Yuwei LIU Jinchun AN Xiuqin CHAI Ru

    1.Shanxi Medical University，Taiyuan 030001，China;2.Department of Gastroenterology， the First Hospital of Shanxi Medical University，Taiyuan 030001，China

    [Abstract] Non-alcoholic fatty liver disease (NAFLD) has become one of the most important chronic liver diseases worldwide at present， and no exact treatment has been determined except lifestyle changes. With the proposal of the gut-liver axis theory， we gradually recognize that intestinal bacteria and their metabolites are closely related to the metabolic status of the host.In addition to intestinal bacteria themselves ......