袁昌丽 杨雷 赵宁辉 吕正超 徐显鑫 王丽娟

    [摘要]?目的?分析催乳素细胞腺瘤患者胰岛素样生长因子-1(insulin-like?growth?factor?1，IGF-1)和胰岛素样生长因子结合蛋白(insulin-like?growth?factor?binding?protein?3，IGFBP-3)的表达及其临床意义。方法?选取2018年1月至2021年12月昆明医科大学第二附属医院收治的60例催乳素细胞腺瘤患者作为研究组，选取同期进行健康体检的60名志愿者作为对照组。比较研究组及对照组IGF-1和IGFBP-3的表达情况及IGF-1/IGFBP-3比值。结果?研究组IGF-1表达水平及IGF-1/IGFBP-3比值均高于对照组，差异均有统计学意义(P0.05)；不同性别的催乳素细胞腺瘤患者IGF-1表达水平及IGF-1/IGFBP-3比值比较，差异无统计学意义(P>0.05)，侵袭性肿瘤患者的IGF-1表达水平及IGF-1/IGFBP-3比值较非侵袭性肿瘤患者高，差异均有统计学意义(P

    [Abstract]?Objective?To?analyze?the?expression?of?insulin-like?growth?factor?1?(IGF-1)?and?insulin-like?growth?factor?binding?protein?3?(IGFBP-3)?in?patients?with?prolactin-cell?adenoma?and?their?clinical?significance.?Methods?A?total?of?60?patients?with?prolactin-cell?adenoma?admitted?to?the?Second?Affiliated?Hospital?of?Kunming?Medical?University?from?January?2018?to?December?2021?were?selected?as?the?study?group ......