倪成香 蔡洁 范霜月 胡国梁

    [摘要]?目的?探究二維斑点追踪成像(two-dimensional?speckle?tracking?imaging，2D-STI)联合三维超声心动图全自动左心定量(three-dimensional?echocardiography?HeartModel，3D-HM)技术在蒽环类药物(anthracycline，ATC)对乳腺癌患者左心室功能损害评估中的应用价值。方法?选取2021年3月至2022年6月于金华市人民医院接受化疗的乳腺癌患者55例，根据化疗第4周期内心电图情况将患者分为心电图正常组(n=19)和心电图异常组(n=36)。分别于化疗前(T0)、化疗第2周期(T1)及第4周期(T2)采用常规超声心动图获取左室射血分数(left?ventricular?ejection?fraction，LVEF)、左室舒张末期容积(left?ventricular?end-diastolic?volume，LVEDV)、左室收缩末期容积(left?ventricular?end-systolic?volume，LVESV)等参数；2D-STI技术获取左室整体纵向应变(global?longitudinal?strain，GLS)参数，3D-HM技术获取3D-LVEF、3D-LVEDV、3D-LVESV等三维参数。结果?T2时，两组患者LVEF水平较T0、T1时均显著下降(P0.05)；T0、T1时，两组患者的GLS水平比较，差异均无统计学意义(P>0.05)；T2时，两组患者GLS水平较T0、T1时均显著下降(P0.05)；T2时，两组患者3D-LVEF水平较T0、T1时显著下降(P0.05)。受试者操作特征曲线分析结果显示，GLS、3D-LVEF及其联合检测评估心电图异常患者左心室功能改变的曲线下面积分别为0.767、0.739和0.788(P

    [Abstract]?Objective?To?investigate?the?application?value?of?two-dimensional?speckle?tracking?imaging?(2D-STI)?combined?with?three-dimensional?echocardiography?HeartModel?(3D-HM)?in?evaluating?anthracycline?(ATC)?induced?damage?to?left?ventricular?function?in?breast?cancer?patients.?Methods?A?total?of?55?breast?cancer?patients?who?received?chemotherapy?at?Jinhua?People's?Hospital?from?March?2021?to?June?2022?were?selected?and?divided?into?normal?electrocardiogram?group?(n=19)?and?abnormal?electrocardiogram?group?(n=36)?according?to?the?electrocardiogram?in?the?4th?cycle?of?chemotherapy.?Parameters?such?as?left?ventricular?ejection?fraction?(LVEF) ......