郭雯雯 张航 许健

    [摘要]?目的?探討血管紧张素转换酶(angiotensin?converting?enzyme，ACE)、载脂蛋白E(apolipoprotein?E，ApoE)基因多态性与高血压患者冠状动脉狭窄程度的相关性。方法?选取2019年1月至2022年2月浙江省中医院收治的180例高血压患者作为研究对象，根据其是否患有冠心病(coronary?heart?disease，CHD)分为对照组(n=85)和CHD组(n=95)，同时根据冠状动脉造影结果将CHD组分为单支病变组(n=25)及多支病变组(n=70)，统计并比较单支病变组与多支病变组ACE基因型、ApoE基因型与等位基因频率的分布，不同冠状动脉病变程度组别ACE基因多态性、ApoE基因多态性分布情况。结果?多支病变组ACE?DD基因型频率和ACE?D等位基因的频率均显著高于单支病变组(P

    [Abstract]?Objective?To?investigate?the?correlation?between?angiotensin-converting?enzyme?(ACE)?and?apolipoprotein?E?(ApoE)?gene?polymorphisms?and?the?degree?of?coronary?stenosis?in?patients?with?hypertension.?Methods?A?total?of?180?hypertensive?patients?admitted?to?Zhejiang?Provincial?Hospital?of?Traditional?Chinese?Medicine?from?January?2019?to?February?2022?were?selected?and?divided?into?the?control?group?(n=85)?and?the?CHD?group?(n=95)?according?to?whether?they?had?coronary?heart?disease?(CHD).?The?distribution?of?ACE?genotype ......