金珍琳 金婷 庄强

    [摘要]?目的?探究艾曲泊帕治療原发免疫性血小板减少症(primary?immune?thrombocytopenia，ITP)患者的回顾性研究。方法?回顾性分析2018年10月至2022年2月于笔者医院接受治疗的90例ITP患者的病历资料，根据不同治疗方式，分为地塞米松组和艾曲泊帕组，地塞米松组采用地塞米松治疗，艾曲泊帕组在地塞米松组基础上联合艾曲泊帕治疗(均n=45)。比较免疫功能、治疗效果及不良反应。结果?治疗后4周，白细胞介素[(interleukin)-2，IL-2]、干扰素-γ(interferon-gamma，INF-γ)水平比较，艾曲泊帕组及地塞米松组均较治疗前降低，且艾曲泊帕组低于地塞米松组，IL-4水平比较，艾曲泊帕组及地塞米松组较治疗前提高，且艾曲泊帕组高于地塞米松组(P0.05)。结论?艾曲泊帕可明显降低ITP患者出血风险，改善免疫功能，提升治疗效果，同时治疗安全性较高。

    [关键词]?艾曲泊帕；原发免疫性血小板减少症；免疫功能；不良反应

    [中图分类号]?R552?[文献标识码]?A?[DOI]?10.3969/j.issn.1673-9701.2024.11.016

    Retrospective?study?on?the?treatment?of?patients?with?primary?immune?thrombocytopenia?with?atrepopa

    JIN?Zhenlin，?JIN?Ting，?ZHUANG?Qiang

    Operating?Room?of?Hematology?Department，?the?First?Affiliated?Hospital?of?Wenzhou?Medical?University，?Wenzhou?325000，?Zhejiang，?China

    [Abstract]?Objective?To?investigate?the?retrospective?study?of?the?treatment?of?primary?immune?thrombocytopenia?(ITP)?with?Aitracopol.?Methods?Medical?records?of?90?patients?with?ITP?who?received?treatment?in?our?hospital?from?October?2018?to?February?2022?were?retrospectively?analyzed?and?grouped?according?to?different?treatment?methods ......