张素婷 许银银

    [摘要]?目的?探討血清白细胞介素(interleukin，IL)-1β和IL-18水平对肺炎严重程度的诊断价值。方法?回顾性选取2022年1月至12月于重庆医科大学附属永川医院治疗的肺炎患者200例，根据肺炎严重程度将其分为轻症组(n=100)和重症组(n=100)，同时纳入在本院体检的健康人100名作为正常组；统计其一般临床资料、血液学指标、热峰、咳嗽、啰音和并发症等临床症状发生情况。对轻症组和重症组患者进行倾向性评分匹配，采用受试者操作特征曲线(receiver?operating?characteristic?curve，ROC曲线)计算匹配前后IL-1β、IL-18诊断重症肺炎的效能。结果?三组受试者的IL-1β、IL-18水平差异均有统计学意义(P轻症组>正常组。匹配前IL-1β、IL-18诊断重症肺炎的截断值分别为12.169pg/ml、194.535pg/ml；IL-1β诊断重症肺炎的诊断效能高于IL-18(0.490?vs.?0.380)。匹配后IL-1β、IL-18诊断重症肺炎的截断值分别为10.542pg/ml、191.372pg/ml。IL-1β诊断重症肺炎的诊断效能高于IL-18(0.493?vs.?0.360)。结论?IL-1β和IL-18随着肺炎严重程度而升高，对重症肺炎具有较高的诊断价值。

    [关键词]?肺炎；白细胞介素-1β；白细胞介素-18；诊断效能

    [中图分类号]?R446.5?[文献标识码]?A?[DOI]?10.3969/j.issn.1673-9701.2024.13.010

    The?diagnostic?significance?of?IL-1β?and?IL-18?in?severe?pneumonia

    ZHANG?Suting，?XU?Yinyin

    Department?of?Clinical?Laboratory，?the?Affiliated?Yongchuan?Hospital?of?Chongqing?Medical?University，?Chongqing?402160，?China

    [Abstract]?Objective?To?explore?the?diagnostic?value?of?serum?interleukin?(IL)?-1β?and?IL-18?levels?in?the?severity?of?pneumonia.?Methods?A?total?of?200?patients?with?pneumonia?treated?in?the?Affiliated?Yongchuan?Hospital?of?Chongqing?Medical?University?from?January?to?December?2022?were?retrospectively?selected?and?divided?into?mild?group?(n=100)?and?severe?group?(n=100)?according?to?the?severity?of?pneumonia ......