邹先翔 邱婷 周洁

    [摘要]?目的?探討多囊卵巢综合征(polycystic?ovary?syndrome，PCOS)患者能否在二甲双胍片联合屈螺酮炔雌醇片(Ⅱ)治疗中获益。方法?选取2021年1月至2022年12月广州市妇女儿童医疗中心确诊的84例PCOS患者。根据治疗方案及稳态模型评估的胰岛素抵抗(homeostasis?model?assessment?of?insulin?resistance，HOMA-IR)指数将患者分为单药正常组[屈螺酮炔雌醇片(Ⅱ)，HOMA-IR指数0.05)。单药正常组和联合用药正常组患者的总有效率比较差异无统计学意义(χ2=3.398，P=0.183)；联合用药异常组患者的总有效率显著高于单药异常组(χ2=6.360，P=0.042)。结论?二甲双胍片联合屈螺酮炔雌醇片(Ⅱ)可改善PCOS患者的胰岛素抵抗，对PCOS合并胰岛素抵抗的患者采用联合方案将获益更多。

    [关键词]?屈螺酮炔雌醇片(Ⅱ)；二甲双胍；多囊卵巢综合征；胰岛素抵抗

    [中图分类号]?R711.5?[文献标识码]?A?[DOI]?10.3969/j.issn.1673-9701.2024.13.018

    Evaluation?of?clinical?benefit?of?metformin?tablets?combined?with?drospirenone?and?ethinylestradiol?tablets?(Ⅱ)?in?the?treatment?of?polycystic?ovary?syndrome

    ZOU?Xianxiang，?QIU?Ting，?ZHOU?Jie

    Department?of?Gynecology，?Guangzhou?Women?and?Childrens?Medical?Center，?Guangzhou?510180，?Guangdong，?China

    [Abstract]?Objective?To?investigate?whether?patients?with?polycystic?ovary?syndrome?(PCOS)?can?benefit?from?metformin?tablets?combined?with?drospirenone?and?ethinylestradiol?tablets?(Ⅱ).?Methods?A?total?of?84?PCOS?patients?diagnosed?in?Guangzhou?Women?and?Childrens?Medical?Center?from?January?2021?to?December?2022?were?selected.?According?to?the?treatment?plan?and?homeostasis?model?assessment?of?insulin?resistance?(HOMA-IR)?index ......