[摘要] 目的 探讨结直肠锯齿状病变(serrated lesions，SL)合并进展期肿瘤(advanced neoplasia，AN)的发生率并分析SL合并AN的危险因素。方法 选取2021年10月1日至2023年9月30日于湖州市第一人民医院行结肠镜检查且术后病理提示为SL的297例患者为研究对象。根据是否合并AN分为合并组(n=33)和非合并组(n=264)，比较两组患者的临床病理差异，并分析SL合并AN的危险因素。结果 年龄≥50岁、男性、有息肉病史、息肉直径及不同的SL分型是SL合并AN的危险因素，两组比较差异有统计学意义(Plt;0.05)。Logistic回归分析，年龄、男性、有息肉病史、SL直径是SL合并AN的独立危险因素。结论 男性、年龄较大、既往息肉病史、SL病变较大的患者更易合并AN。

    [关键词] 锯齿状病变；腺瘤；进展期肿瘤；危险因素

    [中图分类号] R735"" [文献标识码] A"" [DOI] 10.3969/j.issn.1673-9701.2025.20.006

    Analysis of factors affecting colorectal serrated lesions combined with advanced neoplasia

    ZHANG Wentian， YAO Linhua， LU Huifei， YU Jing

    Department of Gastroenterology， the First People’s Hospital of Huzhou， Huzhou 313000， Zhejiang， China

    [Abstract] ObjectiveTo investigate the incidence of colorectal serrated lesions (SL) combined with advanced neoplasia (AN) and to analyze the risk factors for SL combined AN. MethodsA total of 297 patients with colorectal polyps detected by endoscopy and pathologically suggestive of SL from 1st October 2021 to 30th September 2023 in the First People’s Hospital of Huzhou. They were divided into combined group(n=33) and uncomplicated group (n=264) according to whether they were combined with AN or not ......