·文献综述·

    COX-2/Nrf2信号通路在防治前列腺增生症中的研究进展

    全丹妮1，颜苗2，樊新荣1,3*，邓阳1,2，胡乔铭1，刘文琛1

    (1.湖南中医药大学，湖南长沙410208；2.中南大学湘雅二医院药学部，中南大学临床药学研究所，湖南长沙410011；3.中国中医科学院，北京100700)

    〔摘要〕前列腺增生症(benign prostatic hyperplasia,BPH)目前是困扰全球中老年男性最主要的泌尿系统疾病，以下尿路症状为主要临床表现，对患者的生活质量造成了严重的影响。近年来COX-2/Nrf2信号通路的抗炎、抗氧化应激作用得到了证实，炎症及氧化应激在BPH发展过程中的细胞生物学机制也逐渐被阐明，中药基于COX-2/Nrf2信号通路对BPH防治作用得到研究者的关注。本文对COX-2/Nrf2信号通路在防治BPH中的研究进展进行相关阐述。

    〔关键词〕前列腺增生症；COX-2/Nrf2；抗炎；抗氧化

    Research Progress of COX-2/Nrf2Signaling Pathway in Prevention and Treatment of Benign Prostatic Hyperplasia

    QUAN Danni1, YAN Miao2, FAN Xinrong1,3*, DENG Yang1,2, HU Qiaoming1, LIU Wenchen1

    (1. Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; 2. The Second Xiangya Hospital of Central South University, Institute of Clinical Pharmacy of Central South University, Changsha, Hunan 410011, China; 3. China Academy of Chinese Medical Sciences, Beijing 100700, China)

    〔Abstract〕Benign prostatic hyperplasia (BPH) is the most important diseases of urinary system in middle-aged males, and its main clinical manifestations is urinary tract symptoms, which has serious impact on life quality of patients. In recent years, the effects of anti-inflammatory and anti-oxidative stress of COX-2/Nrf2signaling pathway were demonstrated. The cell biological mechanisms of inflammation and oxidative stress in the development of BPH has been elucidated. Based on the COX-2/Nrf2signal pathway, the research of Chinese medicine prevention and treatment of BPH get the attention of us. This paper elaborates the progress of COX-2/Nrf2signaling pathway in the prevention and treatment of BPH. ......