陈菁，冯国湘*

    (1.湘南学院，湖南郴州423000；2.湖南中医药大学第二附属医院，湖南长沙410005)

    艾灸盒温灸对阳虚体质者症状及血清cAMP/cGMP比值的影响

    陈菁1，冯国湘2*

    (1.湘南学院，湖南郴州423000；2.湖南中医药大学第二附属医院，湖南长沙410005)

    目的观察艾灸盒温灸疗法对阳虚体质者症状及血清环磷酸腺苷(cAMP)/环磷酸鸟苷(cGMP)比值的影响，探究阳虚体质与cAMP/cGMP比值的相关性。方法将90例阳虚体质受试者随机分为灸盒组、参附液组、肾气丸组，每组30例，3组均以7 d为1个疗程，连用4个疗程。根据治疗后受试者阳虚质判定评分量表的得分情况评价疗效，同时观察治疗前后血清cAMP/cGMP比值变化情况。结果治疗后，3组受试者阳虚体质转化分均较前显著下降(P<0.01)，灸盒组下降程度高于参附液组和肾气丸组(P<0.05)；3组受试者血清cAMP/cGMP比值均较前下降(P<0.05)，其中灸盒组下降幅度最高(P<0.05)；灸盒组总有效率为53.3%，参附液组总有效率为43.3%；，肾气丸组总有效率40.0%，3组整体疗效相当(P>0.05)。结论艾灸盒温灸能显著改善阳虚体质，cAMP/cGMP与阳虚体质存在一定的相关性。

    阳虚体质；温灸；艾灸盒；环磷酸腺苷；环磷酸鸟苷

    〔Abstract〕Objective To observe the warming box-moxibustion′s effect on symptoms of Yang deficiency constitution and investigate its correlation with on cAMP/cGMP ratio.M ethods A total of 90 Yang deficiency constitution subjects were assigned to warming box-moxibustion group，Shenfu liquid group and Shenqi pill group，30 cases in each group，the groups were given four 7-day courses consecutively.Then the scores of yang deficiency CCMQ(Constitution in Chinese Medicine Questionnaire)were evaluated and the change of cAMP/cGMP ratio before and after treatment was observed.Results The yang deficiency CCMQ scores of the three groupswere decreased after treatment(P<0.01).The decrement of yang deficiency CCMQ scores in box-moxibustion group was higher than those in Shenfu liquid group and Jinkuishenqi pill group(P<0.05).The cAMP/cGMP ratio in serum of the three groups reduce significantly after treatment(P<0.05).The cAMP/cGMP ratio in box-moxibustion group has the highest extent of reducing(P<0.05).After treatment ......