基于系统药理学分析三七总皂苷干预脑血管疾病的作用机制(6)
[19] KISELYOV K， MUALLEM S.ROS and intracellular ion channels[J]. Cell Calcium， 2016，60(2)：108-114.
[20] MENG Q， RICHMOND-BRYANT J， LU S E， et al. Cardiovascular outcomes and the physical and chemical properties of metal ions found in particulate matter air pollution： a QICAR study[J]. Environ Health Perspect， 2013， 121(5)：558-564.
[21] RITCHIE R H， DRUMMOND G R， SOBEY C G， et al. The opposing roles of NO and oxidative stress in cardiovascular disease[J]. Pharmacol Res， 2017， 116： 57-69.
[22] KOH S H， LO E H. The Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarction[J].J ClinNeurol， 2015，11(4)：297-304.
[23] SINGH S S， KANG P M. Mechanisms and inhibitors of apoptosis in cardiovascular diseases[J]. Curr Pharm Des， 2011， 17(18)： 1783-1793.
[24] GOLESTANI R， JUNG J J， SADEGHI M M. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology[J]. J Clin Med. 2016， 5(6)：E57.
[25] WINNIK S， LOHMANN C， SICILIANI G， et al. Systemic VEGF inhibition accelerates experimental atherosclerosis and disrupts endothelial homeostasis-implications for cardiovascular safety[J]. Int J Cardiol， 2013， 168(3)： 2453-2461.
[26] LI X， DEROIDE N， MALLAT Z. The role of the inflammasome in cardiovascular diseases[J]. J Mol Med (Berl)， 2014， 92(4)： 307-319.
[27] HUI Z， SHA D J， WANG S L， et al. Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats[J]. BMC Complement Altern Med， 2017，17(1)：70.
[28] SHI X， YU W， LIU L， et al. Panaxnotoginseng saponins administration modulates pro-/anti-inflammatory factor expression and improves neurologic outcome following permanent MCAO in rats[J]. Metab Brain Dis， 2017， 32(1)：221-233.
[29] XU L， LIU J T， LIU N， et al. Effects of Panaxnotoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells[J]. J Ethnopharmacol， 2011， 137(1)：226-230.
[30] ZHOU N， TANG Y， KEEP R F， et al. Antioxidative effects of Panaxnotoginseng saponins in brain cells[J]. Phytomedicine， 2014， 21(10)：1189-1195.
[31] LI H， DENG C Q， CHEN B Y， et al. Total saponins of Panaxnotoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. J Ethnopharmacol， 2009， 121(3)：412-418.
(本文編辑 杨 瑛), 百拇医药(聂娟 唐标)
[20] MENG Q， RICHMOND-BRYANT J， LU S E， et al. Cardiovascular outcomes and the physical and chemical properties of metal ions found in particulate matter air pollution： a QICAR study[J]. Environ Health Perspect， 2013， 121(5)：558-564.
[21] RITCHIE R H， DRUMMOND G R， SOBEY C G， et al. The opposing roles of NO and oxidative stress in cardiovascular disease[J]. Pharmacol Res， 2017， 116： 57-69.
[22] KOH S H， LO E H. The Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarction[J].J ClinNeurol， 2015，11(4)：297-304.
[23] SINGH S S， KANG P M. Mechanisms and inhibitors of apoptosis in cardiovascular diseases[J]. Curr Pharm Des， 2011， 17(18)： 1783-1793.
[24] GOLESTANI R， JUNG J J， SADEGHI M M. Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology[J]. J Clin Med. 2016， 5(6)：E57.
[25] WINNIK S， LOHMANN C， SICILIANI G， et al. Systemic VEGF inhibition accelerates experimental atherosclerosis and disrupts endothelial homeostasis-implications for cardiovascular safety[J]. Int J Cardiol， 2013， 168(3)： 2453-2461.
[26] LI X， DEROIDE N， MALLAT Z. The role of the inflammasome in cardiovascular diseases[J]. J Mol Med (Berl)， 2014， 92(4)： 307-319.
[27] HUI Z， SHA D J， WANG S L， et al. Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats[J]. BMC Complement Altern Med， 2017，17(1)：70.
[28] SHI X， YU W， LIU L， et al. Panaxnotoginseng saponins administration modulates pro-/anti-inflammatory factor expression and improves neurologic outcome following permanent MCAO in rats[J]. Metab Brain Dis， 2017， 32(1)：221-233.
[29] XU L， LIU J T， LIU N， et al. Effects of Panaxnotoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells[J]. J Ethnopharmacol， 2011， 137(1)：226-230.
[30] ZHOU N， TANG Y， KEEP R F， et al. Antioxidative effects of Panaxnotoginseng saponins in brain cells[J]. Phytomedicine， 2014， 21(10)：1189-1195.
[31] LI H， DENG C Q， CHEN B Y， et al. Total saponins of Panaxnotoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. J Ethnopharmacol， 2009， 121(3)：412-418.
(本文編辑 杨 瑛), 百拇医药(聂娟 唐标)