刘彩霞 邓常清

    〔摘要〕 动脉粥样硬化、冠心病等心血管疾病的病理生理基础是病理性血管重构，而血管内皮细胞(vascular endothelial cell， VEC)功能障碍是病理性血管重构的始动环节。VEC是锚定在基底层、与血液成分和细胞直接接触的单层细胞，是氧化应激、活性氧及其相关信号通路的作用靶点。近年来，中药在治疗心血管疾病方面卓有成效，许多中药复方、中药提取物可通过抗氧化作用保护VEC，调节心血管疾病的发生发展。本文对近年来中药及复方改善VEC氧化应激损伤的作用及其相关机制的研究进行总结，为推动其抗氧化研究及应用提供参考。

    〔关键词〕 血管内皮细胞;氧化应激;心血管疾病;中医药

    〔中图分类号〕R285? ? ? ? 〔文献标志码〕A? ? ? ?〔文章编号〕doi：10.3969/j.issn.1674-070X.2021.01.029

    〔Abstract〕 Pathological vascular remodeling (PVR) is the pathophysiological basis of cardiovascular diseases such as atherosclerosis and coronary heart disease， The initial link of PVR is vascular endothelial cell (VEC) dysfunction. VEC is monolayer endothelial cell， which is anchored in the basal layer and direct contact with components and cells from blood， as the targets of oxidative stress， reactive oxygen species and their related signaling pathways. In recent years， traditional Chinese medicine (TCM) has made great achievements in the treatment of cardiovascular diseases. Many compound prescriptions and the bioactive ingredients of TCM can protect VEC by antioxidant effects ......