杨娅婕 赵宁 曹玉婷 王桂喜

    〔摘要〕 生物标志物对于医学的合理发展至关重要，在科学研究与临床实践中具有重要意义。本文就近年来重复经颅磁刺激治疗中枢神经系统疾病研究中基于生物标志物分析的文献进行总结，发现治疗后中枢神经系统疾病患者的行为学改变与生物标志物的改变呈特定相关性，这些研究的报道可能为经颅磁治疗中枢神经系统疾病提供了更客观的代谢组学证据。

    〔关键词〕 重复经颅磁刺激;生物标记物;神经系统;可塑性;神经递质;氨基酸;炎症;细胞凋亡

    〔中图分类号〕R493;R28? ? ? ?〔文献标志码〕A? ? ? ?〔文章编号〕doi：10.3969/j.issn.1674-070X.2021.03.028

    〔Abstract〕 Biomarkers are very important for the rational development of medicine， and have wide significance in scientific research and clinical practice. We summarized the literatures based on biomarker analysis in the study of repetitive transcranial magnetic stimulation in the treatment of central nervous system diseases in recent years， and found that the behavioral changes of patients with central nervous system diseases after treatment were specifically related to the changes of biomarkers. The reports of these studies may provide more objective metabonomics evidence for transcranial magnetic therapy of central nervous system diseases.

    〔Keywords〕 repetitive transcranial magnetic stimulation; biomarkers; nervous system; plasticity; neurotransmitters; amino acids; inflammation; cell apoptosis ......