符方智 易港 任杰 周青

    〔摘要〕 初步分析提炼前列腺癌及西黄丸相关文献，提出前列腺癌中医病机特点为“虚”“瘀”“毒”“湿”，治疗核心应为扶正和祛邪，临床应根据疾病的正邪盛衰特点调整侧重扶正或祛邪。西黄丸作为治疗恶性肿瘤的经典名方，功效上侧重于祛邪为主，且具有祛邪不伤正的药性特点，可适用于正气充盛或正不甚虚证型前列腺癌。综合现代药理研究进展，西黄丸可介导PI3K/Akt/mTOR信号通路，抑制PC3细胞生长，具有显著的抗肿瘤活性、改善前列腺微环境以及镇痛等作用，认为西黄丸对于前列腺癌患者可能产生较好治疗效果，以期为今后前列腺癌中医临床治疗提供新思路。

    〔关键词〕 前列腺癌;西黄丸;癥积;PI3K/Akt/mTOR信号通路;PC3细胞

    〔中图分类号〕R273 ? ? ? 〔文献标志码〕A ? ? ? ?〔文章编号〕doi：10.3969/j.issn.1674-070X.2022.01.012

    〔Abstract〕 Based on the preliminary analysis and extraction of prostate cancer and Xihuang Pill related literature， it is proposed that the TCM pathogenesis of prostate cancer is characterized by “deficiency”， “stasis”， “toxicity” and “dampness”， and the core of treatment should be strengthening vital Qi and eliminating pathogenic factor， and the clinical adjustment should focus on strengthening vital Qi or eliminating pathogenic factor according to the rise and fall of the disease. Xihuang Pill， as a modern classic prescription for the treatment of cancer diseases， mainly focuses on eliminating pathogenic factor， and has the property of eliminating pathogenic factor without damaging vital Qi ......