张柏雯 邹伟

    〔摘要〕 线粒体自噬发生于脑出血原发性损伤和继发性损伤中，并与脑出血后受损脑组织周围发生的多种生物学效应密切相关，因此探究线粒体自噬对脑出血神经保护机制至关重要。由于脑内微环境在病理状态下的变化，导致多种细胞状态如炎症、凋亡、自噬等发生并对脑神经产生一定的影响，故本文基于线粒体自噬与细胞炎症、凋亡、铁死亡在脑出血继发性损伤中的相互作用关系，探讨线粒体自噬对脑出血后脑组织的神经保护作用。

    〔关键词〕 脑出血;神经保护机制;线粒体自噬;凋亡;炎症;铁死亡

    〔中图分类号〕R285;R743? ? ? ?〔文献标志码〕A? ? ? ? 〔文章编号〕doi：10.3969/j.issn.1674-070X.2022.05.028

    Overview of neuroprotective mechanism of mitochondrial autophagy in intracerebral hemorrhage

    ZHANG Baiwen ZOU Wei

    (1. Heilongjiang University of Chinese Medicine， Harbin， Heilongjiang 150040， China;

    2. The First Affiliated Hospital of Heilongjiang University of Chinese Medicine， Harbin， Heilongjiang 150040， China)

    〔Abstract〕 Mitochondrial autophagy occurs in primary and secondary injury of intracerebral hemorrhage (ICH)， which is closely related to many biological effects around damaged brain tissue after ICH， so it is very important to explore its neuroprotective mechanism of mitochondrial autophagy in ICH. Due to the changes of brain microenvironment in pathological state ......