王聪慧 娄锡恩 卞兆祥

    〔摘要〕 肠道菌群是人体代谢的重要参与者。肠道菌群失调与高尿酸血症(hyperuricemia， HUA)互为因果，肠道菌群结构的紊乱、肠道物质环境的改变以及肠道代谢物的变化皆可导致HUA的发生。中医“脾”之功能健运是肠道稳态的重要条件，而脾失运化则是HUA病机的核心。通过论述肠道菌群、脾与HUA三者之间的关联，探讨HUA的病机特点及科学内涵。

    〔关键词〕 肠道菌群；高尿酸血症；脾主运化；病机；科学内涵

    〔中图分类号〕R259 ? ? ? 〔文献标志码〕A ? ? ? ?〔文章编号〕doi：10.3969/j.issn.1674-070X.2023.04.025

    Scientific connotation of treaing hyperuricemia from a TCM perspective of "spleen-based therapy" based on analysis of intestinal microbiota imbalance

    WANG Conghui1， LOU Xi'en2*， BIAN Zhaoxiang3

    1. The Third Clinical School of Beijing University of Chinese Medicine， Beijing 100029， China; 2. Department of Endocrinology， The Third Hospital of Beijing University of Chinese Medicine， Beijing 100029， China; 3. Shenzhen Research Institute of Hong Kong Baptist University， Shenzhen， Guangdong 518000， China

    〔Abstract〕 The intestinal microbiota plays a significant role in human metabolism. The imbalance of intestinal microbiota are causally related to hyperuricemia (HUA) ......