丛迪迪，梁群，付晨菲，赵佳瑶，王龙

    〔摘要〕 脓毒症急性肺损伤是重症医学科的常见疾病，其病死率高，住院费用高，是危重症疾病领域研究的重点。目前针对脓毒症急性肺损伤的治疗尚无推荐的药理干预措施，中医药基于整体观及辨证论治理念治疗脓毒症急性肺损伤，彰显出多层次、多靶点、多途径的治疗特点，可通过干预炎性因子及炎症信号通路、抗氧化应激、抑制细胞凋亡等途径全面防治脓毒症急性肺损伤。通过回顾总结中医药治疗脓毒症急性肺损伤的实验研究，以期明确其机制和特点，为下一步研发治疗用药提供思路与方向。

    〔关键词〕 脓毒症；急性肺损伤；发病机制；中医药；综述

    〔中图分类号〕R278? ? ? ?〔文献标志码〕A? ? ? ? 〔文章编号〕doi：10.3969/j.issn.1674-070X.2023.07.030

    Review on multi-target intervention mechanism of Chinese

    medicine on sepsis-induced acute lung injury

    CONG Didi1， LIANG Qun1，2*， FU Chenfei1， ZHAO Jiayao1， WANG Long1

    1. Heilongjiang University of Chinese Medicine， Harbin， Heilongjiang 150040， China; 2. The First Hospital of

    Heilongjiang University of Chinese Medicine， Harbin， Heilongjiang 150040， China

    〔Abstract〕 Sepsis-induced acute lung injury (ALI) is a common disease in the intensive care medicine with high mortality and needs high hospitalization cost. It is the research focus of critical illness. However， there has been no recommended pharmacological intervention for its treatment in western medicine. Chinese medicine treats it based on the holistic concept and pattern identification ......