从脾论治溃疡性结肠炎浅析
肠道菌群,免疫功能
〔摘要〕 溃疡性结肠炎(ulcerative colitis,UC)是临床常见但发病机制尚未明确的炎性肠道疾病之一,发病率高,且易复发,其发病机制、诊断和治疗是目前医学研究的热点。中医学多认为脾虚是UC的根本病机,脾虚失运,升降失司,易成泄泻。因此,以脾为本,从脾论治是治疗UC的关键。现代研究发现,运用从脾论治理念治疗UC时,可通过维持肠道菌群稳态、调节线粒体代谢及调节肠道免疫功能平衡,影响UC的发生发展。探讨从脾论治在UC中的作用,依据从脾论治UC的相关机制,将健脾作为从脾论治UC的核心,配合燥湿、疏肝和温肾等治法,以期为有效治疗UC提供新的诊疗角度和治疗思路。〔关键词〕 溃疡性结肠炎;从脾论治;肠道菌群;线粒体;免疫功能;治则治法
〔中图分类号〕R256.34" " " " "〔文献标志码〕A" " " " " 〔文章编号〕doi:10.3969/j.issn.1674-070X.2024.05.020
Brief analysis of treating ulcerative colitis from the spleen
DONG Fengyi1, GAO Zongyue2*, ZHOU Xiaoli3, YANG Yajuan2, WANG Yanyan1,
LIU Yifan1, MO Fan1, WU Jing1
1. The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China; 2. Henan Provincial Hospital of TCM, Zhengzhou, Henan 450002, China; 3. The Third Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450008, China
〔Abstract〕 Clinically, ulcerative colitis (UC) is one of the common inflammatory intestinal diseases with unclear pathogenesis, high morbidity, and easy recurrence. Its pathogenesis, diagnosis, and treatment are currently hot spots in medical research. TCM holds that spleen deficiency is the fundamental pathogenesis of UC ......
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