〔摘要〕 血管性痴呆继发于脑血管疾病，目前已成为老年痴呆的主要类型之一。肠道菌群借助肠-脑轴通过神经、免疫、内分泌和代谢等多种途径实现与大脑之间的双向调控，从而对痴呆等中枢神经退行性病变产生重要影响。中医之阳明与肠道菌群及血管性痴呆在生理、病理方面存在诸多共通之处。从阳明入手，通过调节肠道菌群治疗血管性痴呆成为新的突破点。以肠道菌群为基点，阐释针刺通调阳明治疗血管性痴呆的内涵机制，以期为其临床防治提供新的视角和方法。

    〔关键词〕 血管性痴呆；肠道菌群；阳明；针刺；机制

    〔中图分类号〕R246.6" " " " "〔文献标志码〕A" " " " " 〔文章编号〕doi：10.3969/j.issn.1674-070X.2024.07.021

    Mechanism of unblocking and regulating yangming by acupuncture for vascular dementia based on intestinal flora

    NI Wei1，2， ZHONG Runqi1，2， CHEN Haijiao1，2， ZHANG Jian1，2， LI Shuo3*， LIAO Jiaolu4*

    1. Xiangya Hospital of Central South University， Changsha， Hunan 410008， China; 2. National Clinical Medical Research Center for Geriatric Diseases， Xiangya Hospital of Central South University， Changsha， Hunan 410008， China; 3. Xiangxing College， Hunan University of Chinese Medicine， Yueyang， Hunan 414615， China; 4. Chongqing Hospital of Chinese Medicine， Chongqing 400021， China

    〔Abstract〕 Vascular dementia (VD)， secondary to cerebrovascular disease， has become one of the main types of senile dementia. With the help of the gut-brain axis， intestinal flora can achieve bidirectional regulation with the brain through neurological immune ......