〔摘要〕 “肝”“脑”“目”三者在生理及病理上相互联系，形成了“肝-脑-目”轴交互体系。其关系存在多向交互串扰，影响干眼的发生发展。应用脏腑辨证理论从生理和病理两个层面对“肝-脑-目”轴的内涵进行阐述，并提出“肝-脑-目”轴的3种失衡状态及其与干眼发病的关系，且肝、肾与目的关系为“肝-脑-目”轴理论之关键。提出清肝疏肝以畅“肝-脑-目”轴、益精生髓以充“肝-脑-目”轴、补肝肾阴以理“肝-脑-目”轴的中医药治疗干眼思路，以期为临床治疗干眼提供参考。

    〔关键词〕 干眼；“肝-脑-目”轴；脏腑辨证；肝肾阴虚；清肝疏肝；益精生髓；补肝肾阴

    〔中图分类号〕R276.7" " " " "〔文献标志码〕A" " " " " 〔文章编号〕doi：10.3969/j.issn.1674-070X.2024.07.024

    Treatment of dry eyes with Chinese Medicine based on

    \"liver-brain-eye\" axis

    LEI Junxian1， ZHOU Pai1， PENG Jun1， TIAN Sainan1*， PENG Qinghua1，2*

    1. Hunan University of Chinese Medicine， Changsha， Hunan 410208， China; 2. Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function， Changsha， Hunan 410208， China

    〔Abstract〕 The \"liver\"， \"brain\"， and \"eye\" are intimately connected both physiologically and pathologically， constituting an interactive system known as the \"liver-brain-eye\" axis. This axis exhibits multi-directional interactions and crosstalk， influencing the onset and progression of dry eyes. This paper employs the theory of pattern identification of zang-fu organs to expound on the connotations of the \"liver-brain-eye\" axis from both physiological and pathological perspectives. It proposes three states of disequilibrium within the \"liver-brain-eye\" axis and their associations with the pathogenesis of dry eyes ......