〔摘要〕 血管衰老是多种老年慢性疾病的基础病理过程，而线粒体功能障碍在其发生发展中起关键作用。线粒体的动态调节过程，包括分裂与融合、自噬与生物合成，体现了中医学“阴阳自和”理论中阴阳对立统一与相互转化的观点。文章从“阴阳自和”理论角度出发，探讨线粒体功能障碍在血管衰老中的作用机制，阐明阴阳平衡在维持线粒体功能和血管衰老中的关键作用，旨在为血管衰老的预防和治疗提供理论支持和实践依据。

    〔关键词〕 阴阳自和;线粒体;稳态;血管衰老;线粒体功能障碍

    〔中图分类号〕R226" " " " "〔文献标志码〕A" " " " " 〔文章编号〕doi：10.3969/j.issn.1674-070X.2025.01.015

    Effects of mitochondrial dysfunction on vascular aging based on the theory of \"spontaneous harmonization between yin and yang\"

    ZHANG Yifan1， LUO Xiaoxin1， ZHONG Yan1， BAI Ya'nan1， KONG Weiming1， JIAN Weixiong1，2*

    1. Hunan University of Chinese Medicine， Changsha， Hunan 410208， China; 2. Hunan Key Laboratory of Chinese Medicine Diagnostics， National Key Discipline of Hunan University of Chinese Medicine， Changsha， Hunan 410208， China

    〔Abstract〕 Vascular aging is a fundamental pathological process underlying various chronic diseases in the elderly， with mitochondrial dysfunction playing a critical role in its occurrence and progression. The dynamic regulation process of mitochondria， including fission and fusion， autophagy and biosynthesis， embodies the view of the opposing unity and mutual transformation of yin and yang in the theory of “spontaneous harmonization between yin and yang” in Chinese medicine. Starting from the perspective of “spontaneous harmonization between yin and yang” theory ......