〔摘要〕 中医学认为，脾肾与脑在生理上相互依存、协同作用，病理上亦相互影响。肾藏精生髓，髓聚为脑，依赖于脾主运化，而脾主运化水谷精微，亦滋养脑髓。脾肾功能失调，脑失滋养，直接影响脑神经的发育和功能，与儿童孤独症谱系障碍密切相关。现代医学认为，线粒体是细胞内的“能量工厂”，负责产生ATP，为细胞提供能量。线粒体能量代谢障碍会导致细胞能量供应不足，影响神经元的正常功能和突触连接，进而可能引发儿童孤独症谱系障碍等神经发育障碍。因此，基于脾肾-脑理论，从“线粒体能量代谢障碍”角度，进一步探讨脾肾-脑与线粒体能量代谢的相关性，为儿童孤独症谱系障碍的临床防治提供新的理论依据与实践思路。

    〔关键词〕 孤独症谱系障碍；线粒体；能量代谢；脾肾；脑

    〔中图分类号〕R272" " " " "〔文献标志码〕A" " " " " 〔文章编号〕doi：10.3969/j.issn.1674-070X.2025.03.014

    Treatment of autism spectrum disorder in children based on mitochondrial energy metabolism disorders from the perspective of spleen/kidney-brain

    JI Xiaoxiao1， MA Ning1， CUI Xia2*， ZHANG Ning1， BAI Xue， LI Huifang1， ZHANG Ruijing1，

    GE Lixiu1， HU Ruobing1

    1. The Third Clinical Medical College， Beijing University of Chinese Medicine， Beijing 100029， China; 2. The Third Affiliated Hospital of Beijing University of Chinese Medicine， Beijing 100029， China

    〔Abstract〕 Chinese medicine believes that the spleen/kidney and brain are interdependent and synergistic in physiology， and also influence each part in pathology. The kidney stores essence and generates marrow ......